Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors.
Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors.
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DOI：
10.1124/mol.56.5.851
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发表时间：
1999-11
影响因子：
3.6
通讯作者：
Üzen Savas;K. Griffin;E. F. Johnson
中科院分区：
文献类型：
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作者：
Üzen Savas;K. Griffin;E. F. Johnson
药物暴露可导致特定细胞色素P-450蛋白（P-450）以及II相药物代谢酶的表达增加，这可极大地增强治疗药物的代谢和清除。动物模型已被用于评估药物诱导P-
Drug exposures can lead to an increased expression of specific cytochrome P-450 proteins (P-450s) as well as of phase II drug-metabolizing enzymes that can greatly augment the metabolism and clearance of therapeutic drugs. Animal models have been used to estimate the potential of drugs to induce P-