Channel-facilitated membrane transport: Transit probability and interaction with the channel
Channel-facilitated membrane transport: Transit probability and interaction with the channel
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DOI：
10.1063/1.1475758
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发表时间：
2002-06-08
影响因子：
4.4
通讯作者：
Bezrukov, SM
中科院分区：
文献类型：
--
作者：
Berezhkovskii, AM;Pustovoit, MA;Bezrukov, SM
细胞之间和亚细胞区室之间的代谢物的运输是由特殊的蛋白质通道，形成贯穿生物膜的水孔促进。越来越多的证据表明，溶质特异性通道显示出明显的结合相应的溶质。在本文中，我们合理的观察表明，一个宽而深的势阱内的通道是能够大大增加粒子通过通道的过境概率。利用一维扩散模型和辐射边界条件，我们给出了粒子移位几率的精确解析表达式。我们还运行布朗动力学模拟来验证模型和我们的理论的定量预测。(C)2002年美国物理学会。
Transport of metabolites between cells and between subcellular compartments is facilitated by special protein channels that form aqueous pores traversing biological membranes. Accumulating evidence demonstrates that solute-specific channels display pronounced binding to the corresponding solutes. In this paper we rationalize this observation by showing that a wide and deep potential well inside the channel is able to greatly increase the transit probability of the particle through the channel. Using a one-dimensional diffusion model with radiation boundary conditions, we give exact analytical expressions for the particle translocation probabilities. We also run Brownian dynamics simulations to verify the model and the quantitative predictions of our theory. (C) 2002 American Institute of Physics.