CLINICAL USEFULNESS OF URINARY 3-METHYLHISTIDINE EXCRETION IN INDICATING MUSCLE PROTEIN BREAKDOWN
CLINICAL USEFULNESS OF URINARY 3-METHYLHISTIDINE EXCRETION IN INDICATING MUSCLE PROTEIN BREAKDOWN
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DOI：
10.1136/bmj.282.6261.351
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发表时间：
1981-01-01
影响因子：
105.7
通讯作者：
SMITH, R
中科院分区：
文献类型：
--
作者：
ELIA, M;CARTER, A;SMITH, R
在与氮丢失相关的情况下，测量了来自收缩蛋白肌动蛋白和肌球蛋白的翻译后修饰氨基酸3-甲基组氨酸的尿排出量。严重损伤、甲状腺功能亢进症、肿瘤、强的松龙治疗和Duchenne肌营养不良症患者的肌原纤维蛋白分解率的指标3-甲基组氨酸/肌酐排泄率的比值升高。粘液性肿胀、骨软化、体温过低的比例降低，饥饿、择期手术、类风湿性关节炎影响不大。如果饮食是无肉的，尿3-甲基组氨酸的测定可能会为蛋白质丢失的原因提供有用的信息。
Urinary excretion of the post translationally modified amino-acid 3-methylhistidine, derived from the contractile proteins actin and myosin, was measured in patients with conditions associated with N loss. The ratio of 3-methylhistidine:creatinine excretion, a measure of the fractional catabolic rate of myofibrillar protein, was increased in severe injury, thyrotoxicosis, neoplastic disease, prednisolone administration and sometimes Duchenne muscular dystrophy. In myxedema, osteomalacia and hypothermia, the ratio was decreased; starvation, elective operations and rheumatoid arthritis had little effect. Provided that the diet is meat-free, measurement of urinary 3-methylhistidine may provide useful information on the cause of protein loss.