Long-term potentiation of neuronal excitation in the central nucleus of the rat amygdala revealed by imaging with a voltage-sensitive dye
Long-term potentiation of neuronal excitation in the central nucleus of the rat amygdala revealed by imaging with a voltage-sensitive dye
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DOI：
10.1016/j.brainres.2010.06.039
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发表时间：
2010-08-19
期刊：
影响因子：
2.9
通讯作者：
Murase, Kazuyuki
中科院分区：
文献类型：
--
作者：
Kiritoshi, Takaki;Ikeda, Hiroshi;Murase, Kazuyuki
我们研究了从中央核的大鼠杏仁核（CeA）切片神经元兴奋的传播模式，使用光学成像与电压敏感染料。我们分析了条件刺激诱导神经元兴奋的长时程增强（LTP）机制。高频条件刺激诱导的NMDA受体，cAMP和PKA依赖的LTP的神经元兴奋的外侧部分的CeA。毛喉素的浴应用也诱导LTP是PICA-dependent。这些结果表明，在CeA的外侧部分的神经元兴奋的增强是由细胞内cAMP/PICA信号的激活，这是由Ca 2+通过NMDA受体的内流触发。(C)2010爱思唯尔有限公司版权所有。
We examined the propagation pattern of neuronal excitation in slices from the central nucleus of the rat amygdala (CeA) using optical imaging with a voltage-sensitive dye. We analyzed the mechanisms for the long-term potentiation (LTP) of neuronal excitation induced by conditioning stimulation. High-frequency conditioning stimulation induced NMDA receptor-, cAMP-, and PKA-dependent LTP of neuronal excitation in the lateral part of the CeA. The bath application of forskolin also induced LTP that was PICA-dependent. These results suggest that the potentiation of neuronal excitation in the lateral part of the CeA is induced by the activation of intracellular cAMP/PICA signaling, which is triggered by the influx of Ca2+ via NMDA receptors. (C) 2010 Elsevier B.V. All rights reserved.