Evolution of resistance to Bt crops:: directional selection in structured environments
Evolution of resistance to Bt crops:: directional selection in structured environments
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DOI：
10.1046/j.1461-0248.2002.00392.x
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发表时间：
2002-11-01
期刊：
影响因子：
8.8
通讯作者：
Andow, DA
中科院分区：
文献类型：
--
作者：
Ives, AR;Andow, DA
广泛使用转基因作物，表达来自苏云金芽孢杆菌的杀虫内毒素，增加了欧洲玉米螟和其他昆虫害虫进化抗性的风险。为了延缓抗性进化，正在对Bt玉米和Bt棉花实施高剂量避难所策略。我们开发了一个通用的建模框架来了解赋予抗性的等位基因的入侵和传播。我们发现，至少有三个过程参与解释高剂量避难所策略的有效性：选择的强度，由于空间细分的选择性（非随机）交配，以及由于空间细分的男性交配成功的变化。了解这些过程会导致更大范围的可能的阻力管理策略。例如，鼓励成年人离开纳塔尔场的努力可能会加速而不是减缓抵抗力进化的不良影响。此外，当Bt玉米对易感目标害虫造成高死亡率时，在避难所喷洒杀虫剂以减少害虫种群可能不会大大破坏抗性管理。
Widespread use of transgenic crops that express an insecticidal endotoxin from Bacillus thuringiensis increases the risk of evolution of resistance by the European corn borer and other insect pests. To delay resistance evolution, the high-dose refuge strategy is being implemented for Bt maize and Bt cotton. We develop a general modelling framework to understand the invasion and spread of alleles conferring resistance. We show that at least three processes are involved in explaining the effectiveness of the high-dose refuge strategy: the intensity of selection, assortative (non-random) mating due to spatial subdivision, and variation in male mating success also due to spatial subdivision. Understanding these processes leads to a greater range of possible resistance management tactics. For example, efforts to encourage adults to leave their natal fields may have the unwanted effect of speeding rather than slowing resistance evolution. Furthermore, when Bt maize causes high mortality to susceptible target pests, spraying insecticides in refuges to reduce pest populations may not greatly disrupt resistance management.