Recent advances in the study of zebrafish extracellular matrix proteins
Recent advances in the study of zebrafish extracellular matrix proteins
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DOI：
10.1016/j.ydbio.2014.12.022
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发表时间：
2015-05-01
影响因子：
2.7
通讯作者：
Jessen, Jason R.
中科院分区：
文献类型：
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作者：
Jessen, Jason R.
斑马鱼的细胞外基质（ECM）是一个动态的和多形性的结构组成的许多蛋白质，共同调节各种细胞和形态发生事件早在原肠胚形成。斑马鱼基因组编码与在其他脊椎动物生物体中发现的ECM蛋白类似的补体，包括糖蛋白、纤维蛋白、蛋白聚糖、糖胺聚糖和相互作用或修饰蛋白，如整联蛋白和基质金属蛋白酶。作为一种遗传模型系统，结合其对高分辨率显微成像的适应性，斑马鱼允许在胚胎和成体中询问ECM蛋白的结构和功能。不断积累的数据已经确定了斑马鱼ECM蛋白在细胞极性、迁移、组织力学、器官偏侧性、肌肉收缩和再生等过程中的重要作用。在这篇综述中，我强调最近发表的数据，这些主题，展示了ECM蛋白纤连蛋白，层粘连蛋白和胶原蛋白如何有助于斑马鱼的发展和成人的体内平衡。(C)2014 Elsevier Inc. All rights reserved.
The zebrafish extracellular matrix (ECM) is a dynamic and pleomorphic structure consisting of numerous proteins that together regulate a variety of cellular and morphogenetic events beginning as early as gastrulation. The zebrafish genome encodes a similar complement of ECM proteins as found in other vertebrate organisms including glycoproteins, fibrous proteins, proteoglycans, glycosaminoglycans, and interacting or modifying proteins such as integrins and matrix metalloproteinases. As a genetic model system combined with its amenability to high-resolution microscopic imaging, the zebrafish allows interrogation of ECM protein structure and function in both the embryo and adult. Accumulating data have identified important roles for zebrafish ECM proteins in processes as diverse as cell polarity, migration, tissue mechanics, organ laterality, muscle contraction, and regeneration. In this review, I highlight recently published data on these topics that demonstrate how the ECM proteins fibronectin, laminin, and collagen contribute to zebrafish development and adult homeostasis. (C) 2014 Elsevier Inc. All rights reserved.