Biomechanical computed tomography-noninvasive bone strength analysis using clinical computed tomography scans
Biomechanical computed tomography-noninvasive bone strength analysis using clinical computed tomography scans
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DOI：
10.1111/j.1749-6632.2009.05348.x
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发表时间：
2010-01-01
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影响因子：
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通讯作者：
Keaveny, Tony M.
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文献类型：
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作者：
Keaveny, Tony M.
结合有限元建模，生物力学，和临床计算机断层扫描（CT）扫描-生物力学CT（BCT）-是一个强大的研究技术，无创评估全骨强度，现在正在使用的临床研究。该技术得到了尸体研究的充分支持，为药物治疗效果提供了大量新的见解，可以比双能X线吸收测定法（DXA）更早地显示治疗效果，并且在骨折风险评估中显示出比MA更高的灵敏度。由于该技术可用作先前采集的包含髋关节或脊柱的CT扫描的辅助“附加”分析，因此应该可以以高度成本效益的方式在临床上实施该技术。这种策略，如果应用于那些以前没有测试DXA，有可能大大增加的个人被确定为高风险的骨质疏松性骨折的数量。
The combination of finite element modeling, biomechanics, and clinical computed tomography (CT) scanning-biomechanical CT (BCT)-is a powerful research technique for noninvasive assessment of whole-bone strength and is now being used in clinical research studies. Well supported by cadaver studies, the technique is providing substantial new insight into drug treatment effects, can show treatment effects earlier than dual-energy X-ray absorptiometry (DXA), and has shown greater sensitivity than MA in fracture risk assessment. Because the technique can be used as an ancillary "add-on" analysis to previously acquired CT scans containing either the hip or spine, it should be possible to implement this technology clinically in a highly cost-effective manner. This strategy, if applied to those not previously tested by DXA, has the potential to greatly increase the number of individuals identified as being at high risk for osteoporotic fracture.