New horizons in the analysis of circulating cell-derived microparticles
New horizons in the analysis of circulating cell-derived microparticles
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DOI：
10.2302/kjm.53.210
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发表时间：
2004-12-01
影响因子：
2
通讯作者：
Ahn, Yeon S.
中科院分区：
文献类型：
--
作者：
Horstman, Lawrence L.;Jy, Wenche;Ahn, Yeon S.
对循环细胞衍生的微粒(MP)的分析正变得更加精细和临床有用。这篇评论源于2003年底在东京的演讲，没有重复以前的评论，而是聚焦于新的地平线。一个主要的主题是越来越多的人认识到血小板及其MP(PMP)是炎症/免疫的关键介质。发展的主要概念包括：(I)许多所谓的炎症可溶性标志物实际上是MP结合的；(Ii)PMP和其他MP似乎具有重要的信号和免疫功能，包括抗原递呈。总而言之，MP分析即将进入临床测试的主流，测量特定的抗原而不是粗略水平。然而，需要更多的研究来果断地确定它们的功能，并且需要国际标准来比较不同实验室的结果。
Analysis of circulating cell-derived microparticles (MP) is becoming more refined and clinically useful. This review, stemming from lectures given at Tokyo late 2003, does not repeat prior reviews but focusses on new horizons. A major theme is the rising recognition of platelets and their MP (PMP) as key mediators of inflammation/immunity. Among the major concepts developed are that (i) many so-called soluble markers of inflammation are in reality MP-bound; (ii) PMP and other MP appear to serve important signaling and immune functions including antigen presentation. In conclusion, MP analysis is poised to enter the mainstream of clinical testing, measuring specific antigens rather than gross levels. However, more research is needed to decisively establish their functions, and international standards are needed to allow comparing results from different laboratories.