KINETICS OF CARRIER-MEDIATED ION TRANSPORT ACROSS LIPID BILAYER MEMBRANES
KINETICS OF CARRIER-MEDIATED ION TRANSPORT ACROSS LIPID BILAYER MEMBRANES
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DOI：
10.1016/0005-2736(70)90251-8
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发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
STARK, G
中科院分区：
文献类型：
--
作者：
LAUGER, P;STARK, G
本文对大环离子载体存在下脂双层膜的电导和示踪剂渗透性进行了理论研究。该分析是基于离子和载体之间的复合物形成在膜-溶液界面的假设。复合物跨膜的易位被描述为在活化能势垒上的运输。结果表明，一些信息的速率常数可以从现有的电导测量。例如，卵磷脂膜在单肌动蛋白存在下的电流电压特性表明，离子转运中的速率决定步骤是复合物穿过膜内部的易位。
A theoretical treatment of the electrical conductance and tracer permeability of lipid bilayer membranes in the presence of macrocyclic ion carriers is given. The analysis is based on the assumption that the complex between the ion and the carrier is formed in the membrane-solution interface. The translocation of the complex across the membrane is described as a transport over an activation energy barrier. It is shown that some information on the rate constants may be obtained from the existing conductance measurements. For instance, the current voltage characteristic of lecithin membranes in the presence of monactin indicates that the rate-determining step in the ion transport is the translocation of the complex across the interior of the membrane.