Preparation of an injectable depot system for long-term delivery of alendronate and evaluation of its anti-osteoporotic effect in an ovariectomized rat model
Preparation of an injectable depot system for long-term delivery of alendronate and evaluation of its anti-osteoporotic effect in an ovariectomized rat model
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DOI：
10.1016/j.ijpharm.2015.01.020
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发表时间：
2015-03-01
影响因子：
5.8
通讯作者：
Park, Jin Woo
中科院分区：
文献类型：
--
作者：
Bae, Joonho;Park, Jin Woo
We prepared an injectable depot system for the long-term delivery of alendronate using a solid/water/oil/ water multiple emulsion technique with poly(lactic-co-glycolic acid) as a carrier. The microparticles were spherical with smooth surfaces, ranging from 20 to 70 mu m in size. The microspheres (ALD-HARG504H- MC70) were optimally prepared by introducing a viscous material (hyaluronic acid) and a co-solvent system in the inner aqueous and oil phases, respectively, and showed a significantly increased drug encapsulation efficacy (>70%); the initial burst release was
