Ageing Is Associated with Decreases in Appetite and Energy Intake--A Meta-Analysis in Healthy Adults.
Ageing Is Associated with Decreases in Appetite and Energy Intake--A Meta-Analysis in Healthy Adults.
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DOI：
10.3390/nu8010028
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发表时间：
2016-01-07
期刊：
影响因子：
5.9
通讯作者：
Soenen S
中科院分区：
文献类型：
--
作者：
Giezenaar C;Chapman I;Luscombe-Marsh N;Feinle-Bisset C;Horowitz M;Soenen S
人们还没有很好地认识到，在老年人中，体重减轻比体重增加更常见。这项分析的目的是通过对至少包括两个年龄组（>18岁）的试验进行荟萃分析，确定隔夜禁食后和餐后状态下年龄对食欲（饥饿/饱胀）和能量摄入的影响。我们假设健康老年人的食欲和能量摄入量低于年轻人。在截至2015年6月30日的PubMed数据库系统检索后，随机效应模型荟萃分析纳入了59项研究。老年人（n = 3574/~70岁/~71 kg/~25 kg/m2）的能量摄入比年轻人（n = 4111/~26岁/~69 kg/~23 kg/m2）低16%-20%（标准化平均差异：−0.77（95%置信区间−0.90至−0.64））。老年人的饥饿感比年轻人低25%（隔夜禁食后;加权平均差（WMD）：−17（−22至−13）mm）至39%（餐后状态; WMD：−14（−19至−9）mm），饱胀感比年轻人高37%（隔夜禁食后; WMD：6 mm（95%CI：1至11 mm））。总之，健康老年人的食欲和能量摄入量低于年轻人，这表明衰老本身会影响食物摄入。
It is not well recognized that in the elderly weight loss is more common than weight gain. The aim of this analysis was to determine the effect of ageing on appetite (hunger/fullness) and energy intake, after overnight fasting and in a postprandial state, by meta-analyses of trials that included at least two age groups (>18 years). We hypothesized that appetite and energy intake would be less in healthy older compared with younger adults. Following a PubMed-database systematic search up to 30 June 2015, 59 studies were included in the random-effects-model meta-analyses. Energy intake was 16%–20% lower in older (n = 3574/~70 years/~71 kg/~25 kg/m2) than younger (n = 4111/~26 years/~69 kg/~23 kg/m2) adults (standardized mean difference: −0.77 (95% confidence interval −0.90 to −0.64)). Hunger was 25% (after overnight fasting; weighted mean difference (WMD): −17 (−22 to −13) mm) to 39% (in a postprandial state; WMD: −14 (−19 to −9) mm) lower, and fullness 37% (after overnight fasting; WMD: 6 mm (95% CI: 1 to 11 mm)) greater in older than younger adults. In conclusion, appetite and energy intake are less in healthy older than younger adults, suggesting that ageing per se affects food intake.