Perfusion CT of the brain: Diagnostic approach for early detection of ischemic stroke
Perfusion CT of the brain: Diagnostic approach for early detection of ischemic stroke
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DOI：
10.1148/radiology.209.1.9769817
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发表时间：
1998-10-01
期刊：
影响因子：
19.7
通讯作者：
Heuser, L
中科院分区：
文献类型：
--
作者：
Koenig, M;Klotz, E;Heuser, L
目得：为了确定灌注计算机断层扫描（CT）在中风患者的临床研究中的价值，并比较结果与单光子发射CT（SPECT）findings.MATERIALS AND METHODS：灌注CT在6小时内进行症状发作的32例可能中风。根据CT结果计算脑血容量（CBV）、脑血流量（CBF）和造影剂强化达峰时间。脑SPECT也进行了一个亚组的18名患者。在逐病灶分析中比较灌注CT和SPECT结果。灌注CT结果与随访CT和磁共振imaging findings.RESULTS：在28例确诊为梗死的患者中，25例（敏感性，89%）的灌注CT辅助下检测到CBF减少的区域。16例患者中13例（81%）的CBF图结果与SPECT结果符合良好，但另外3例患者的缺血位于扫描平面之外，因此被漏诊。灌注CT显示不同的变化，CBF，CBV，和时间达到峰值增强缺血regions.CONCLUSION：灌注CT不仅可以早期检测脑缺血，但也产生有价值的信息灌注紊乱的程度。
PURPOSE: To determine the value of perfusion computed tomography (CT) in a clinical study of patients with stroke and compare the results with single photon emission CT (SPECT) findings.MATERIALS AND METHODS: Perfusion CT was performed within 6 hours of symptom onset in 32 patients with possible stroke. Cerebral blood volume (CBV), cerebral blood flow (CBF), and time to peak contrast material enhancement were calculated on the basis of the CT results. Cerebral SPECT was also performed in a subgroup of 18 patients. Perfusion CT and SPECT findings were compared in a lesion-by-lesion analysis. Perfusion CT results were compared with follow-up CT and magnetic resonance imaging findings.RESULTS: Areas of reduced CBF were detected with the aid of perfusion CT in 25 of 28 patients with a proved infarct (sensitivity, 89%). The results of the CBF maps corresponded well to SPECT finding sin 13 (81%) of 16 patients, but ischemia was located outside the scanning level in the other three patients and was therefore missed. Perfusion CT revealed various changes in CBF, CBV, and time to peak enhancement in ischemic territories.CONCLUSION: Perfusion CT not only allows early detection of cerebral ischemia but also yields valuable information about the extent of perfusion disturbances.