A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.
A web resource for mining HLA associations with adverse drug reactions: HLA-ADR.
复制标题
DOI：
10.1093/database/baw069
复制
发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Jones, Andrew R
中科院分区：
文献类型：
--
作者：
Ghattaoraya, Gurpreet S;Dundar, Yenal;Jones, Andrew R
人类白细胞抗原(人类白细胞抗原)是参与免疫系统的一个重要基因家族。它们的主要功能是使宿主免疫系统能够区分自体和非自体多肽--例如源自入侵的病原体。然而，这些基因也与免疫介导的药物不良反应(ADR)有关，给患者、临床医生和制药公司带来了一个问题。我们之前已经开发了等位基因频率网络数据库(AFND)，该数据库捕获了来自世界各地的许多健康人群中这些HL A基因的等位基因和单倍型频率。在这里，我们报告了人类白细胞抗原-ADR数据库的开发和发布，该数据库收集了人类白细胞抗原等位基因和单倍型与药物不良反应相关的文献数据(例如，史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症和药物性肝损伤)。使用通过系统回顾文献和半自动文献挖掘获得的数据来创建HL A-ADR。该数据库还利用AFND中已有的数据，允许用户比较和分析ADR患者和健康人群中的等位基因频率。人类白细胞抗原-ADR数据库为临床医生和研究人员提供了一个研究免疫介导的ADR的集中资源。数据库网址：http://www.allelefrequencies.net/hla-adr/.
Human leukocyte antigens (HLA) are an important family of genes involved in the immune system. Their primary function is to allow the host immune system to be able to distinguish between self and non-self peptides-e.g. derived from invading pathogens. However, these genes have also been implicated in immune-mediated adverse drug reactions (ADRs), presenting a problem to patients, clinicians and pharmaceutical companies. We have previously developed the Allele Frequency Net Database (AFND) that captures the allelic and haplotype frequencies for these HLA genes across many healthy populations from around the world. Here, we report the development and release of the HLA-ADR database that captures data from publications where HLA alleles and haplotypes have been associated with ADRs (e.g. Stevens-Johnson Syndrome/toxic epidermal necrolysis and drug-induced liver injury). HLA-ADR was created by using data obtained through systematic review of the literature and semi-automated literature mining. The database also draws on data already present in AFND allowing users to compare and analyze allele frequencies in both ADR patients and healthy populations. The HLA-ADR database provides clinicians and researchers with a centralized resource from which to investigate immune-mediated ADRs.Database URL: http://www.allelefrequencies.net/hla-adr/.