Clathrin: a role in the intracellular retention of a Golgi membrane protein.
Clathrin: a role in the intracellular retention of a Golgi membrane protein.
复制标题
网格蛋白：在高尔基体膜蛋白的细胞内保留中发挥作用。
DOI：
10.1126/science.2675311
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Schekman,R
中科院分区：
文献类型：
--
作者：
Payne,GS;Schekman,R
Yeast mutants deficient in the clathrin heavy chain secrete a precursor form of the α-factor, a peptide-mating pheromone. Analysis of this defect indicates that the endoprotease Kex2p, which is responsible for initiating proteolytic maturation of the α-factor precursor in the Golgi apparatus, is unexpectedly present at the plasma membrane in mutant cells. This result suggests that clathrin is required for the retention of Kex2p in the Golgi apparatus.
