A Nationwide Epidemiological Survey of Adolescent Patients With Diverse Symptoms Similar to Those Following Human Papillomavirus Vaccination: Background Prevalence and Incidence for Considering Vaccine Safety in Japan.
A Nationwide Epidemiological Survey of Adolescent Patients With Diverse Symptoms Similar to Those Following Human Papillomavirus Vaccination: Background Prevalence and Incidence for Considering Vaccine Safety in Japan.
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DOI：
10.2188/jea.je20210277
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发表时间：
2022-01-05
影响因子：
4.7
通讯作者：
Sobue T
中科院分区：
文献类型：
--
作者：
Fukushima W;Hara M;Kitamura Y;Shibata M;Ugawa Y;Hirata K;Oka A;Miyamoto S;Kusunoki S;Kuwabara S;Hashimoto S;Sobue T
自2013年6月以来，由于自我报告的多种症状，包括疼痛和运动功能障碍，日本已暂停主动推荐人乳头瘤病毒（HPV）疫苗接种，这些症状可能是免疫接种后的严重不良事件。虽然这些症状可能出现在没有接种HPV疫苗的青少年中，但考虑到疾病的严重程度，尚未检查其频率。2016年进行了一项两阶段的描述性全国流行病学调查，目标期为2015年7月1日至12月31日，为期6个月，以估计未接种HPV疫苗的日本青少年中各种症状的患病率和发生率。调查对象为全国范围内分层随机抽样的11,037家医院的医疗部门。符合条件的患者必须满足四个标准：（1）就诊时年龄为12-18岁;（2）具有四种症状/障碍（疼痛或感觉功能障碍、运动功能障碍、自主神经功能障碍或认知障碍）中的至少一种;（3）症状/障碍持续至少3个月;以及（4）标准（2）和（3）均影响上学或工作。然后，我们提取了与HPV疫苗接种后类似的各种症状的患者的数据，同时考虑了主管医生的意见。在未接种HPV疫苗的12-18岁女孩中，估计6个月期间各种症状的患病率为每10万人20.2人。年发病率估计为每10万人7.3人。未接种HPV疫苗的日本少女也出现了与接种HPV疫苗后类似的各种症状。我们的研究结果预测了同时发生的各种症状的医疗需求，这些症状与日本青少年的HPV疫苗接种在时间上相关，但不是由HPV疫苗接种引起的。
Since June 2013, Japan has suspended proactive recommendation of human papillomavirus (HPV) vaccination due to self-reported diverse symptoms, including pain and motor dysfunction, as possible serious adverse events following immunization. Although these symptoms may be seen in adolescents without HPV vaccination, their frequency, taking into account disease severity, has not been examined. A two-stage, descriptive, nationwide epidemiological survey was conducted in 2016, with a 6-month target period from July 1 to December 31, 2015, to estimate the prevalence and incidence of diverse symptoms among Japanese adolescents without HPV vaccination. Participants were 11,037 medical departments in hospitals selected nationwide by stratified random sampling. Eligible patients had to satisfy four criteria: (1) aged 12–18 years upon visiting hospital; (2) having at least one of four symptoms/disorders (pain or sensory dysfunction, motor dysfunction, autonomic dysfunction, or cognitive impairment); (3) symptoms/disorders persisting for at least 3 months; and (4) both criteria (2) and (3) influence attendance at school or work. We then extracted data of patients with diverse symptoms similar to those after HPV vaccination while considering opinions of doctors in charge. Estimated 6-month period prevalence of diverse symptoms among girls aged 12–18 years without HPV vaccination was 20.2 per 100,000. Annual incidence was estimated to be 7.3 per 100,000. Adolescent Japanese girls without HPV vaccination also visited hospitals with diverse symptoms similar to those following HPV vaccination. Our findings predict the medical demands for coincident diverse symptoms, which are temporally associated with but not caused by HPV vaccination of Japanese adolescents.
影响因子：
1
作者：
Ogawa Y;Takei H;Ogawa R;Mihara K
通讯作者：
Mihara K