Neuroanatomical precursors of dyslexia identified from pre-reading through to age 11
Neuroanatomical precursors of dyslexia identified from pre-reading through to age 11
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DOI：
10.1093/brain/awu229
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发表时间：
2014-12-01
期刊：
影响因子：
14.5
通讯作者：
Hugdahl, Kenneth
中科院分区：
文献类型：
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作者：
Clark, Kristi A.;Helland, Turid;Hugdahl, Kenneth
发展性阅读障碍是一种常见的阅读障碍，对个体的识字能力产生负面影响。虽然涉及阅读的大脑网络及其在阅读障碍中的功能障碍已经得到了很好的研究，但阅读障碍是由阅读网络本身的结构异常还是由向阅读网络提供输入的低级别网络的结构异常引起的尚不清楚。在这项研究中，我们获得了结构磁共振成像扫描纵向从27挪威儿童正式识字训练开始之前，直到诵读困难被诊断出来。因此，我们能够确定，在阅读障碍之前的主要神经解剖学异常不是在阅读网络本身，而是在负责听觉和视觉处理以及核心执行功能的较低级别区域。阅读网络本身的缺失只在11岁时观察到，在孩子们学会如何阅读之后。研究结果表明，异常的阅读网络的结果有不同的阅读经验，而不是阅读障碍本身，而神经解剖学的前体主要是在初级感觉皮层。
Developmental dyslexia is a common reading disorder that negatively impacts an individual's ability to achieve literacy. Although the brain network involved in reading and its dysfunction in dyslexia has been well studied, it is unknown whether dyslexia is caused by structural abnormalities in the reading network itself or in the lower-level networks that provide input to the reading network. In this study, we acquired structural magnetic resonance imaging scans longitudinally from 27 Norwegian children from before formal literacy training began until after dyslexia was diagnosed. Thus, we were able to determine that the primary neuroanatomical abnormalities that precede dyslexia are not in the reading network itself, but rather in lower-level areas responsible for auditory and visual processing and core executive functions. Abnormalities in the reading network itself were only observed at age 11, after children had learned how to read. The findings suggest that abnormalities in the reading network are the consequence of having different reading experiences, rather than dyslexia per se, whereas the neuroanatomical precursors are predominantly in primary sensory cortices.