Hydrogel-Based Organic Subdural Electrode with High Conformability to Brain Surface
Hydrogel-Based Organic Subdural Electrode with High Conformability to Brain Surface
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DOI：
10.1038/s41598-019-49772-z
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发表时间：
2019-09
影响因子：
4.6
通讯作者：
Shuntaro Oribe;S. Yoshida;Shinya Kusama;S. Osawa;A. Nakagawa;M. Iwasaki;T. Tominaga;M. Nishizawa
中科院分区：
文献类型：
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作者：
Shuntaro Oribe;S. Yoshida;Shinya Kusama;S. Osawa;A. Nakagawa;M. Iwasaki;T. Tominaga;M. Nishizawa
通过将聚（3，4-乙撑二氧噻吩）修饰的碳纤维（PEDOT-CF）阵列嵌入聚乙烯醇（PVA）水凝胶基底中，研制了一种完全柔软的有机硬膜下电极。可拉伸PEDOT-CF的网状结构允许与PVA基底稳定的结构整合。在生理盐水、单次活体脑组织以及大鼠和猪的活体动物实验中评价了用于监测皮层电图（ECoG）的电极性能。结果表明，PEDOT-CF的大双层电容在包括癫痫发作的脑电波频率下带来低阻抗，并且PVA水凝胶基底使脑上的接触阻抗最小化。基于水凝胶的ECoG电极的最重要的独特特征是其形状顺应性，即使仅通过放置也能够紧密粘附到大脑的弯曲的凹槽表面。此外，由于基于水凝胶的电极是完全有机的，因此可以在没有图像伪影的情况下进行同步ECoG-fMRI测量，避免了由传统金属电极引起的问题。
A totally soft organic subdural electrode has been developed by embedding an array of poly(3,4-ethylenedioxythiophene)-modified carbon fabric (PEDOT-CF) into the polyvinyl alcohol (PVA) hydrogel substrate. The mesh structure of the stretchable PEDOT-CF allowed stable structural integration with the PVA substrate. The electrode performance for monitoring electrocorticography (ECoG) was evaluated in saline solution, onex vivobrains, andin vivoanimal experiments using rats and porcines. It was demonstrated that the large double-layer capacitance of the PEDOT-CF brings low impedance at the frequency of brain wave including epileptic seizures, and PVA hydrogel substrate minimized the contact impedance on the brain. The most important unique feature of the hydrogel-based ECoG electrode was its shape conformability to enable tight adhesion even to curved, grooved surface of brains by just being placed. In addition, since the hydrogel-based electrode is totally organic, the simultaneous ECoG-fMRI measurements could be conducted without image artifacts, avoiding problems induced by conventional metallic electrodes.