State-dependent encoding of sound and behavioral meaning in a tertiary region of the ferret auditory cortex
State-dependent encoding of sound and behavioral meaning in a tertiary region of the ferret auditory cortex
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DOI：
10.1038/s41593-018-0317-8
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发表时间：
2019-03-01
影响因子：
25
通讯作者：
Fritz, Jonathan B.
中科院分区：
文献类型：
--
作者：
Elgueda, Diego;Duque, Daniel;Fritz, Jonathan B.
在更高级的感觉皮质中，有一个从感觉到感知和行动的逐渐转变。在听觉系统中，这种变化通过嘴侧腹后听域(VPR)的反应来揭示，VPR是雪貂听觉皮质的第三区域，与幼稚的动物相比，它显示了训练有素的动物的长期学习，源于对行为相关目标刺激的选择性增强反应。在主动执行频谱或时间听觉辨别任务期间，这种增强的表征被进一步放大。VPR还显示出目标刺激抵消后持续的短期记忆活动，与任务反应时间和动作相关。这些与任务相关的听觉过滤器特性变化使VPR神经元能够快速灵活地在对相同声刺激的不同反应之间切换，反映声音的频谱特性、时间或行为意义。此外，它们展示了短期注意和长期学习的动态之间的相互作用，因为传入的声音被选择性地注意、识别并转化为行动。
In higher sensory cortices, there is a gradual transformation from sensation to perception and action. In the auditory system, this transformation is revealed by responses in the rostral ventral posterior auditory field (VPr), a tertiary area in the ferret auditory cortex, which shows long-term learning in trained compared to naive animals, arising from selectively enhanced responses to behaviorally relevant target stimuli. This enhanced representation is further amplified during active performance of spectral or temporal auditory discrimination tasks. VPr also shows sustained short-term memory activity after target stimulus offset, correlated with task response timing and action. These task-related changes in auditory filter properties enable VPr neurons to quickly and nimbly switch between different responses to the same acoustic stimuli, reflecting either spectrotemporal properties, timing, or behavioral meaning of the sound. Furthermore, they demonstrate an interaction between the dynamics of short-term attention and long-term learning, as incoming sound is selectively attended, recognized, and translated into action.