Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material
Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material
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新型磁共振信号增强涂层材料含Gd3聚合物复合物的制备
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Chang
中科院分区：
文献类型：
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作者：
Jian Guo;Xiqun Jiang;Yong Hu;Chang
摘要本文研究了一种含Gd3+的聚合物配合物作为磁共振信号增强涂层材料的适用性。Gd>的合成
AbstractThis study investigated the suitability of a Gd3+-containing polymer complex used as a magnetic resonance (MR) signal-enhancing coating material. The synthesis of the Gd>
3+-containing polymer complex was done by conjugating N-(2-hydroxyethyl)ethylenediaminetriacetic acid (HEDTA) with poly (styrene-maleic acid) copolymer (SMA), followed by coordinating with Gd3+. The characterizations of FT-IR, NMR and XPS confirmed that HEDTA was covalently attached to SMA and Gd3+-containing polymer complex was formed. Coating such Gd3+-containing polymer complex on the surface of polypropylene (PP) catheter was performed by solution coating method. The results of MR imaging experiments in vitro indicated that the PP catheter coated with this coating material showed strong MR signal in the vicinity of the catheter surface and a clear contrast between the catheter surface and background. Based on these results, a novel MR signal-enhancing coating material, which showed the great potentialities in making catheters for endovascular intervention, visible by MR imaging, can be developed.