Biofoundries are a nucleating hub for industrial translation.
Biofoundries are a nucleating hub for industrial translation.
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DOI：
10.1093/synbio/ysab013
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Freemont PS
中科院分区：
文献类型：
--
作者：
Farzaneh T;Freemont PS
当代合成生物学涵盖了整个创新管道;它是一个变革性的技术平台，影响新的应用并改进现有的工业产品和工艺。然而，在作为价值链组成部分的上游和下游流程的交界处仍然出现挑战。现在很明显，生物制品在解决这一问题方面发挥着关键作用;它们提供了独特且可访问的基础设施，以推动必要的标准化，从而实现生物系统和工作流程的系统设计和工程。至于其他生物工厂，伦敦生物工厂的成功部分归功于其通过广泛的战略合作建立工业翻译渠道的专业知识。它还成为各种财团和伙伴关系的关键组成部分，为更广泛的生物经济和工业战略服务。采用网络化的方法可以使基础设施、研究人员、工业家和政策制定者之间建立联系，以降低规模扩大带来的经济挑战的风险，并为不断增长的生物经济做出贡献。
Contemporary synthetic biology embraces the entire innovation pipeline; it is a transformative technology platform impacting new applications and improving existing industrial products and processes. However, challenges still emerge at the interface of upstream and downstream processes, integral to the value chain. It is now clear that biofoundries have a key role to play in addressing this; they provide unique and accessible infrastructure to drive the standardization necessary to deliver systematic design and engineering of biological systems and workflows. As for other biofoundries, the success of the London Biofoundry has been in part due to its expertise in establishing channels for industrial translation through its extensive strategic collaborations. It has also become cemented as a key component of various consortia and partnerships that serve the broader bioeconomy and industrial strategies. Adopting a networked approach enables links to be made between infrastructure, researchers, industrialists and policy makers to de-risk the economic challenges of scale-up, as well as contribute to the growing bioeconomy.