Clinical, morphological, and biochemical correlates of head circumference in autism
Clinical, morphological, and biochemical correlates of head circumference in autism
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DOI：
10.1016/j.biopsych.2007.04.039
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发表时间：
2007-11-01
影响因子：
10.6
通讯作者：
Persico, Antonio M.
中科院分区：
文献类型：
--
作者：
Sacco, Roberto;Militerni, Roberto;Persico, Antonio M.
背景：自闭症患者的头部生长速度通常会加快。本研究的目的是在定义的临床，形态学和生化相关的头围在自闭症patients.Methods：额枕部头围测量241名非综合征型自闭症患者，3至16岁，诊断根据DSM-IV标准。我们评估了1）使用自闭症诊断观察表、自闭症诊断访谈修订版、Vineland适应行为量表、智商测量和特别临床病史问卷的临床参数; 2）身高和体重; 3）血清素（5-HT）血液水平和肽尿。颅围的分布明显偏向较大的头部（p97百分位数）通常是更广泛的巨大体内表型的一部分，其特征在于头围，体重，和身高（p第75百分位数与更多受损的适应性行为相关，与智商测量和运动及口头语言发育的受损较少相关。令人惊讶的是，较大的头部尺寸显着相关的过敏性/免疫疾病的患者和他/她的一级relatives.Conclusions的积极历史：我们的研究表明，存在一个巨大的内表型自闭症和指向与免疫功能障碍，我们推测要么导致或相关的细胞周期进程增加和/或细胞凋亡减少的发病联系。
Background: Head growth rates are often accelerated in autism. This study is aimed at defining the clinical, morphological, and biochemical correlates of head circumference in autistic patients.Methods: Fronto-occipital head circumference was measured in 241 nonsyndromic autistic patients, 3 to 16 years old, diagnosed according to DSM-IV criteria. We assessed 1) clinical parameters using the Autism Diagnostic Observation Schedule, Autism Diagnostic Interview-Revised, Vineland Adaptive Behavioral Scales, intelligence quotient measures, and an ad hoc clinical history questionnaire; 2) height and weight; 3) serotonin (5-HT) blood levels and peptiduria.Results: The distribution of cranial circumference is significantly skewed toward larger head sizes (p 97th percentile) is generally part of a broader macrosomic endophenotype, characterized by highly significant correlations between head circumference, weight, and height (p 75th percentile is associated with more impaired adaptive behaviors and with less impairment in IQ measures and motor and verbal language development. Surprisingly, larger head sizes are significantly associated with a positive history of allergic/immune disorders both in the patient and in his/her first-degree relatives.Conclusions: Our study demonstrates the existence of a macrosomic endophenotype in autism and points toward pathogenetic links with immune dysfunctions that we speculate either lead to or are associated with increased cell cycle progression and/or decreased apoptosis.