Sex steroids and affect in the surgical menopause: a double-blind, cross-over study
Sex steroids and affect in the surgical menopause: a double-blind, cross-over study
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性类固醇及其对手术绝经的影响：一项双盲交叉研究
DOI：
10.1016/0306-4530(85)90009-5
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发表时间：
1985
影响因子：
3.7
通讯作者：
M. Gelfand
中科院分区：
文献类型：
--
作者：
B. Sherwin;M. Gelfand
采用前瞻性、双盲、交叉设计研究了雌激素和/或雄激素对手术绝经妇女情绪的影响。与安慰剂组（PL）相比，接受雌激素（E）、雄激素（A）或胃肠外雌激素-雄激素联合制剂（E-A）的卵巢切除妇女在两个治疗阶段获得了较低的抑郁评分，这与她们较高的血浆雌激素和睾酮水平一致。当激素被撤回，抑郁症评分的所有卵巢切除妇女显着高于卵巢切除的对照组（CON）。A组的敌意得分也高于E组、PL组和CON组。这些数据提供了雌激素和睾酮循环水平与健康女性的某些影响之间存在协变的证据。
The effect of estrogen and/or androgen on mood in surgically menopausal women was investigated with a prospective, double-blind, cross-over design. Oophorectomized women who received either estrogen (E), androgen (A), or a combined estrogen - androgen preparation (E - A) parenterally attained lower depression scores during both treatment phases compared to a placebo group (PL), coincident with their higher plasma estrogen and testosterone levels. When steroids were withdrawn, depression scores of all oophorectomized women were significantly higher than those of a hysterectomized control group with intact ovaries (CON). The A group also had higher hostility scores than the E, PL, and CON groups. These data provide evidence of a covariation between circulating levels of estrogen and testosterone and certain affects in healthy women.