c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis
c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis
复制标题
人中枢神经系统神经元中c-Mpl和TPO的表达抑制神经元凋亡
DOI：
10.18632/aging.103086
复制
发表时间：
2020-04-30
期刊：
影响因子：
5.2
通讯作者：
Yang, Mo
中科院分区：
文献类型：
--
作者：
Li, Liang;Yi, Chenju;Yang, Mo
Thrombopoietin (TPO) is a growth factor for the megakaryocytic/platelet lineage. In this study, we investigated the expression of TPO and its receptor, c-Mpl, in the human central nervous system (CNS) and their roles after a neural insult. Our results demonstrate that both TPO and c-Mpl are expressed in the neurons of the human CNS. TPO was also detected in human cerebrospinal fluid. TPO was found to be neuroprotective in hypoxic-ischemic neonatal rat brain models. In these rat models, treatment with TPO reduced brain damage and improved sensorimotor functions. In addition, TPO promoted C17.2 cell proliferation through activation of the PI3K/Akt signaling pathway. Via the Bcl-2/BAX signaling pathway, TPO exerted an antiapoptotic effect by suppressing mitochondrial membrane potentials. Taken together, our results indicate that TPO is neuroprotective in the CNS.
