In vivo study of endometriosis in mice by photoacoustic microscopy
In vivo study of endometriosis in mice by photoacoustic microscopy
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DOI：
10.1002/jbio.201300189
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Li, Changhui
中科院分区：
文献类型：
--
作者：
Ding, Yichen;Zhang, Mingzhu;Li, Changhui
子宫内膜异位症 (EM) 影响育龄妇女的医疗保健和生活质量。然而，无论是动物研究还是临床应用，都没有可靠的无创诊断方法。在这项工作中，采用了一种新颖的成像方法——光声显微镜（PAM）来研究小鼠模型上的电磁。我们的结果表明，PAM 无创地为裸鼠体内皮下植入的 EM 组织提供高对比度和 3D 成像。统计研究还表明，在本动物研究中，PAM 对 EM 的诊断具有较高的敏感性和特异性。此外，我们还讨论了 PAM 在 EM 诊断中的潜在临床应用。
Endometriosis (EM) impacts the healthcare and the quality of life for women of reproductive age. However, there is no reliable noninvasive diagnosis method for either animal study or clinical use. In this work, a novel imaging method, photoacoustic microscopy (PAM) was employed to study the EM on the mouse model. Our results demonstrated the PAM noninvasively provided the high contrast and 3D imaging of subcutaneously implanted EM tissue in the nude mouse in vivo. The statistical study also indicated PAM had high sensitivity and specificity in the diagnosis of EM in this animal study. In addition, we also discussed the potential clinical application for PAM in the diagnosis of EM.