Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006.
Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006.
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DOI：
10.1186/1471-2334-8-94
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发表时间：
2008-07-18
影响因子：
3.7
通讯作者：
Varma, Jay K.
中科院分区：
文献类型：
--
作者：
Lolekha, Rangsima;Anuwatnonthakate, Amornrat;Nateniyom, Sriprapa;Sumnapun, Surin;Yamada, Norio;Wattanaamornkiat, Wanpen;Sattayawuthipong, Wanchai;Charusuntonsri, Pricha;Sanguanwongse, Natpatou;Wells, Charles D.;Varma, Jay K.
在每年发生的920万新结核病例中，约10%是儿童。由于儿童结核病通常是非传染性和非致命性的，因此国家计划不优先考虑儿童结核病的诊断和治疗。我们回顾了一个示范项目的数据，以了解更多关于泰国儿童结核病流行病学的信息。在泰国的四个省和一家国立医院，我们每月联系医疗机构，记录结核病诊断者的数据，协助患者护理，提供艾滋病毒咨询和检测，并获取痰液进行培养和敏感性检测。我们分析了2005年和2006年登记的年龄< 15岁患者的临床和治疗结果数据。在14，487例病例中，只有279例（2%）发生在儿童中。儿童的中位年龄为8岁（范围：4个月，14岁）。在197名患有肺结核的儿童中，63人（32%）经细菌学确诊：56人（28%）涂片阳性，7人（4%）涂片阴性，但培养阳性。其中一人被诊断患有耐多药结核病。75例（27%）记录了艾滋病毒感染。75名感染艾滋病毒的儿童中有13名（17%）在结核病治疗期间死亡，而204名未知感染艾滋病毒的儿童中有4名（2%）死亡（p < 0.01）。儿童结核病在泰国很少被诊断出来。了解这是否是由于缺乏疾病或诊断工作需要进一步的研究。艾滋病毒是泰国儿童结核病负担的主要原因，并与高死亡率有关。
Of the 9.2 million new TB cases occurring each year, about 10% are in children. Because childhood TB is usually non-infectious and non-fatal, national programs do not prioritize childhood TB diagnosis and treatment. We reviewed data from a demonstration project to learn more about the epidemiology of childhood TB in Thailand. In four Thai provinces and one national hospital, we contacted healthcare facilities monthly to record data about persons diagnosed with TB, assist with patient care, provide HIV counseling and testing, and obtain sputum for culture and susceptibility testing. We analyzed clinical and treatment outcome data for patients age < 15 years old registered in 2005 and 2006. Only 279 (2%) of 14,487 total cases occurred in children. The median age of children was 8 years (range: 4 months, 14 years). Of 197 children with pulmonary TB, 63 (32%) were bacteriologically-confirmed: 56 (28%) were smear-positive and 7 (4%) were smear-negative, but culture-positive. One was diagnosed with multi-drug resistant TB. HIV infection was documented in 75 (27%). Thirteen (17%) of 75 HIV-infected children died during TB treatment compared with 4 (2%) of 204 not known to be HIV-infected (p < 0.01). Childhood TB is infrequently diagnosed in Thailand. Understanding whether this is due to absence of disease or diagnostic effort requires further research. HIV contributes substantially to the childhood TB burden in Thailand and is associated with high mortality.
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影响因子：
3.8
作者：
Mukadi, YD;Wiktor, SZ;Greenberg, AE
通讯作者：
Greenberg, AE
影响因子：
3.6
作者：
Palme, IB;Gudetta, B;Giesecke, J
通讯作者：
Giesecke, J
影响因子：
168.9
作者：
Zar, HJ;Honslo, D;Hussey, G
通讯作者：
Hussey, G
影响因子：
3.8
作者：
Plipat, Tanarak;Naiwatanakul, Thananda;Culnane, Mary
通讯作者：
Culnane, Mary
DOI：
10.2471/blt.06.038067
发表时间：
2007-08-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Varma, Jay K;Wiriyakitjar, Daranee;Tappero, Jordan W
通讯作者：
Tappero, Jordan W