Auditory deviance detection revisited: Evidence for a hierarchical novelty system
Auditory deviance detection revisited: Evidence for a hierarchical novelty system
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DOI：
10.1016/j.ijpsycho.2011.05.012
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发表时间：
2012-07-01
影响因子：
3
通讯作者：
Escera, Caries
中科院分区：
文献类型：
--
作者：
Grimm, Sabine;Escera, Caries
对新刺激或异常刺激的快速检测是听觉加工的一个显著特性，它反映了听觉系统的基本组织原理，同时也具有很高的现实意义。在人体电生理学中，异常检测与失配负性（MMN）的发生有关，失配负性是事件相关电位（ERP）的一个组成部分，在罕见的不规则声音发生100至250毫秒后被唤起。最近，动物研究表明，听觉通路中相当一部分神经元表现出一种称为刺激特异性适应的特性，使它们能够编码声音间的关系，并以更高的速率放电以应对声音刺激的罕见变化。这些神经反应与在人类头皮测量的异常诱发电位有关，但与MMN相比，这些反应在解剖学上发生在较低的水平（例如，初级听觉皮层和下丘），并且更早（在声音响起后20-30毫秒）被激发。此外，它们的大小不足以被解释为MMN的直接神经关联。我们回顾了一系列最近的研究结果，这些发现为填补动物和人类记录之间的空白提供了第一步，表明在人类中可以观察到由声音偏差引起的相对较早的调制，特别是在声音开始后的前50毫秒内ERP的中潜伏期部分。这些偏差检测的早期指标先于被充分研究的MMN成分的存在，有力地支持了规则编码和违规检测是人类听觉加工多层次作用的基本原则的观点。这支持了人类听觉系统中分层组织的新奇和偏差检测系统的概念。(C) 2011 Elsevier B.V.版权所有
The fast detection of novel or deviant stimuli is a striking property of the auditory processing which reflects basic organizational principles of the auditory system and at the same time is of high practical significance. In human electrophysiology, deviance detection has been related to the occurrence of the mismatch negativity (MMN) - a component of the event-related potential (ERP) evoked 100 to 250 ms after the occurrence of a rare irregular sound. Recently, it has been shown in animal studies that a considerable portion of neurons in the auditory pathway exhibits a property called stimulus-specific adaptation enabling them to encode inter-sound relationships and to discharge at higher rates to rare changes in the acoustic stimulation. These neural responses have been linked to the deviant-evoked potential measured at the human scalp, but such responses occur at lower levels anatomically (e.g. the primary auditory cortex as well as the inferior colliculi) and are elicited earlier (20-30 ms after sound onset) in comparison to MMN. Further, they are not considerable enough in size to be interpreted as a direct neural correlate of the MMN. We review here a series of recent findings that provides a first step toward filling this gap between animal and human recordings by showing that comparably early modulations due to a sound's deviancy can be observed in humans, particularly in the middle-latency portion of the ERP within the first 50 ms after sound onset. The existence of those early indices of deviance detection preceding the well-studied MMN component strongly supports the idea that the encoding of regularities and the detection of violations is a basic principle of human auditory processing acting on multiple levels. This sustains the notion of a hierarchically organized novelty and deviance detection system in the human auditory system. (C) 2011 Elsevier B.V. All rights reserved.