ON DEVELOPMENT OF BONE MARROW INNERVATION IN NEW-BORN RATS AS STUDIED WITH SILVER IMPREGNATION AND ELECTRON MICROSCOPY
ON DEVELOPMENT OF BONE MARROW INNERVATION IN NEW-BORN RATS AS STUDIED WITH SILVER IMPREGNATION AND ELECTRON MICROSCOPY
复制标题
DOI：
10.1002/aja.1001260308
复制
发表时间：
1969-01-01
影响因子：
--
通讯作者：
FORTEZAV.J
中科院分区：
文献类型：
--
作者：
CALVO, W;FORTEZAV.J
这项对新生大鼠骨髓神经支配的研究表明，在出生后第二周结束时，神经中出现了主要的分化迹象。有髓神经纤维开始获得髓鞘在这个时候。雪旺氏细胞有丰富的内质网。其中一些细胞将单个轴突分开，并用形成髓鞘的双层膜包裹它们。从那时起，骨髓的神经包含有髓纤维和无髓纤维。成纤维细胞也在此期间分化，在神经周围产生胶原纤维。一些成纤维细胞通过桥粒样结构相互连接。成纤维细胞和胶原纤维形成神经的结缔组织鞘（神经束膜和神经内膜）。当雪旺细胞完成髓鞘和成纤维细胞完成结缔组织鞘时，骨髓神经获得成年动物外周神经的形态学特征。与动脉壁的肌纤维接触的轴突的精细结构对应于瓦塔里的2-a型。这些神经纤维被认为是交感神经类型。骨髓中神经成熟的时间与其他作者在该器官中证明的对刺激和抑制条件的反应的开始相一致。
This study of innervation of the bone marrow in new‐born rats demonstrates that major signs of differentiation occur in the nerves at the end of the second week after birth. Myelinated nerve fibers begin to acquire their myelin sheath at this time. The Schwann cells show abundant ergastoplasmic reticulum. Some of these cells separate individual axons and wrap them up with the double membranes that form the myelin sheath. From then on, the nerves of the marrow contain both myelinated and nonmyelinated fibers. Fibroblasts also differentiate during this time, producing collagen fibers around the nerves. Some fibroblasts are interconnected by desmosome‐like structures. Fibroblasts and collagen fibers form the connective tissue sheaths of the nerve (perineurium and endoneurium). Upon completion of the myelin sheath by the Schwann cells and the connective tissue sheath by the fibroblasts, nerves of the marrow acquire the morphological characteristics of the peripheral nerves of the adult animal. The fine structure of the axons in contact with the muscle fibers of the arterial wall correspond to Type 2‐a of Watari. These nerve fibers are considered to be of sympathetic type. The time of maturation of nerves in the bone marrow coincides with the beginning of responsiveness to stimulatory and inhibitory conditions demonstrated in this organ by other authors.