Comparative study of platelet angiotensin II binding and the angiotensin II sensitivity test as predictors of pregnancy-induced hypertension.
Comparative study of platelet angiotensin II binding and the angiotensin II sensitivity test as predictors of pregnancy-induced hypertension.
复制标题
血小板血管紧张素 II 结合和血管紧张素 II 敏感性测试作为妊娠高血压预测因子的比较研究。
DOI：
10.1042/cs0830089
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发表时间：
1992
期刊：
影响因子：
6
通讯作者：
E. M. Symonds
中科院分区：
文献类型：
--
作者：
P. Baker;F. B. Pipkin;E. M. Symonds
1.测定了34例妊娠晚期妇女（妊娠28 ~ 32周）的血小板血管紧张素II结合率，并测定了其对血管紧张素II输注的升压反应。2.血小板血管紧张素II结合率与血管紧张素II输注舒张期升压反应相关曲线斜率之间存在显著相关性（P <0.01），表明两种技术之间存在共线性，并支持使用血小板血管紧张素II结合率作为血管平滑肌升压反应模型。3. 34名妇女中有10名随后患上了妊娠高血压。随后发生妊娠高血压患者的血小板血管紧张素II结合率是血压正常患者的6倍（P <0.001）。然而，在血管紧张素II输注实验得出的任何参数中，组间无显著差异。4.单独使用血小板血管紧张素II结合预测妊娠结局，使用判别分析进行评估，比使用任何输注参数时更成功，77%的患者被正确分类。
1. Platelet angiotensin II binding was measured in 34 primigravid women (between 28 and 32 weeks gestation), in whom the pressor response to infused angiotensin II was also determined. 2. There was a significant correlation between the platelet angiotensin II binding and the slope of the curve relating the diastolic pressor response to infused angiotensin II (P less than 0.01), suggesting that co-linearity between the two techniques exists and supporting the use of platelet angiotensin II binding as a model of vascular smooth muscle pressor responsiveness. 3. Ten of the 34 women subsequently developed pregnancy-induced hypertension. Platelet angiotensin II binding in the patients who subsequently developed pregnancy-induced hypertension was sixfold higher than in the patients who remained normotensive (P less than 0.001). There were, however, no significant differences between the groups in any of the parameters derived from the angiotensin II infusion experiments. 4. The use of platelet angiotensin II binding alone in predicting the outcome of the pregnancies, as assessed using discriminant analysis, was more successful than when any of the infusion parameters were used, with 77% of patients being correctly classified.