Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats
Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats
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白藜芦醇可预防大鼠慢性不可预测的轻度应激引起的认知受损
DOI：
10.1016/j.pnpbp.2013.10.017
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发表时间：
2014-03-03
影响因子：
5.6
通讯作者：
Wang, Zhen
中科院分区：
文献类型：
--
作者：
Liu, Dexiang;Zhang, Qingrui;Wang, Zhen
抑郁症是最常见的神经精神障碍之一，与认知受损以及导致神经内分泌系统和脑蛋白质改变有关。白藜芦醇是一种富含虎杖的天然多酚，具有多种生物活性，包括强大的抗抑郁作用。这项研究的目的是确定白藜芦醇是否影响慢性不可预测的轻度应激(CUMS)诱导的认知障碍，并探索潜在的机制。结果表明，在Morris水迷宫和新物体识别任务中，CUMS(5周)能有效地造成大鼠的认知障碍。此外，暴露于CUMS可显著提高血清皮质酮水平，降低前额叶皮质(PFC)和海马区BDNF水平，同时降低细胞外信号调节蛋白(PERK)和cAMP反应元件结合蛋白(PCREB)的磷酸化水平。长期给予白藜芦醇(80 mg/kg，i.p，5周)可显著阻止所有这些由CUMS引起的行为和生化改变。综上所述，我们的研究表明，白藜芦醇可能是一种有效的治疗认知障碍的药物，其神经保护作用部分是通过调节血清皮质酮水平、上调BDNF、pCREB和PERK水平来实现的。(C)2013 Elsevier Inc.保留所有权利。
Depression is one of the most common neuropsychiatric disorders and has been associated with impaired cognition, as well as causing neuroendocrine systems and brain proteins alterations. Resveratrol is a natural polyphenol enriched in polygonum cuspidatum and has diverse biological activities, including potent antidepressantlike effects. The aim of this study was to determine whether resveratrol administration influences chronic unpredictable mild stress (CUMS)-induced cognitive deficits and explores underlying mechanisms. The results showed that CUMS (5 weeks) was effective in producing cognitive deficits in rats as indicated by Morris water maze and novel object recognition task. Additionally, CUMS exposure significantly elevated serumcorticosterone levels and decreased BDNF levels in the prefrontal cortex (PFC) and hippocampus, accompanied by decreased phosphorylation of extracellular signal-regulated kinase (pERK) and cAMP response element-binding protein (pCREB). Chronic administration of resveratrol (80 mg/kg, i.p., 5 weeks) significantly prevented all these CUMS-induced behavioral and biochemical alterations. In conclusion, our study shows that resveratrol may be an effective therapeutic agent for cognitive disturbances aswas seenwithin the stressmodel and its neuroprotective effectwas mediated in part by normalizing serumcorticosterone levels, up-regulating of the BDNF, pCREB and pERK levels. (C) 2013 Elsevier Inc. All rights reserved.