GRAPHITE - A MIMIC FOR DNA AND OTHER BIOMOLECULES IN SCANNING TUNNELING MICROSCOPE STUDIES
GRAPHITE - A MIMIC FOR DNA AND OTHER BIOMOLECULES IN SCANNING TUNNELING MICROSCOPE STUDIES
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DOI：
10.1126/science.1992517
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发表时间：
1991-02-08
期刊：
影响因子：
56.9
通讯作者：
BEEBE, TP
中科院分区：
文献类型：
--
作者：
CLEMMER, CR;BEEBE, TP
高度有序热解石墨 (HOPG) 是 DNA 等生物分子的扫描隧道显微镜 (STM) 研究中常用的基材。 本文中提供的所有图像都是新劈裂的 HOPG 表面，未发生沉积。 这些图像展示了以前被认为是由生物分子引起的特征，例如“分子”在步骤上的周期性和蜿蜒。 这些特征不能再用于区分真实分子和天然底物的特征。 讨论了继续使用 HOPG 作为生物 STM 研究底物的可行性。
Highly ordered pyrolytic graphite (HOPG) is the substrate often used in scanning tunneling microscope (STM) studies of biomolecules such as DNA. All of the images presented in this article are of freshly cleaved HOPG surfaces upon which no deposition has occurred. These images illustrate features previously thought to be due to biological molecules, such as periodicity and meandering of "molecules" over steps. These features can no longer be used to distinguish real molecules from features of the native substrate. The feasibility of the continued use of HOPG as a substrate for biological STM studies is discussed.