Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome
Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome
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DOI：
10.1042/cs1010739
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发表时间：
2001-12-01
期刊：
影响因子：
6
通讯作者：
Tayek, JA
中科院分区：
文献类型：
--
作者：
Khani, S;Tayek, JA
Android肥胖与皮质醇分泌增加有关。在正常人中测定了皮质醇对胰岛素抵抗的发生和其他参数的直接影响。使用Haymond和Sunehag的倒数池模型（HS法）和Tayek和Katz的科里循环/乳酸盐稀释法（TK法）测定葡萄糖异生。在3 h基线输注和4-8 h垂体-胰腺输注生长抑素、替代胰岛素、生长激素（GH）、胰高血糖素和高剂量皮质醇（氢化可的松）后，测量葡萄糖产生（GP）和新生儿。垂体-胰腺输注将胰岛素、GH和胰高血糖素浓度维持在空腹范围内，同时仅增加一种激素皮质醇的浓度。两组5名受试者分别给予高剂量皮质醇给药，并将结果与一组6名“单独禁食”受试者（无输液）在禁食16和20小时的结果进行比较。各组的空腹GP（空腹12小时）相似，平均为12.5 ± 0.2 μ mol.min（-1）.kg（-1）。使用HS法和TK法时，糖异生（以GP的百分比表示）分别为35 +/- 2%和40 +/- 2%。禁食16小时后，GP下降（11.5 +/- 0.6 μ mol .结果表明，用HS法和TK法测定的GP值分别为55 ± 5%和57 ± 5%（P < 0.05）。高剂量皮质醇输注4小时可增加血清皮质醇（660 +/- 30 nmol/l; P < 0.05）、血糖（7.9 +/- 0.5 mmol/l; P < 0.05）和GP（14.8 +/- 0.8 mol.min（-1）.kg（-1）; P
Android obesity is associated with increased cortisol secretion. Direct effects of cortisol on gluconeogenesis and other parameters of insulin resistance were determined in normal subjects. Gluconeogenesis was determined using the reciprocal pool model of Haymond and Sunehag (HS method), and by the Cori cycle/lactate dilution method of Tayek and Katz (TK method). Glucose production (GP) and gluconeogenesis were measured after a 3 h baseline infusion and after a 4-8 h pituitary-pancreatic infusion of somatostatin, replacement insulin, growth hormone (GH), glucagon and a high dose of cortisol (hydrocortisone). The pituitary-pancreatic infusion maintains insulin, GH and glucagon concentrations within the fasting range, while increasing the concentration of only one hormone, cortisol. Two groups of five subjects were each given high-dose cortisol administration, and results were compared with those from a group of six 'fasting alone' subjects (no infusion) at 16 and 20 h of fasting. Fasting GP (12 h fasting) was similar in all groups, averaging 12.5 +/- 0.2 mu mol.min(-1).kg(-1). Gluconeogenesis, as a percentage of GP, was 35 +/- 2% using the HS method and 40 +/- 2% using the TK method. After 16 h of fasting, GP had fallen (11.5 +/- 0.6 mu mol . min(-1).kg(-1)) and gluconeogenesis had increased (55 +/- 5% and 57 +/- 5% of GP by the HS and TK methods respectively; P < 0.05). High-dose cortisol infusion for 4 h increased serum cortisol (660 +/- 30 nmol/l; P < 0.05), blood glucose (7.9 +/- 0.5 mmol/l; P < 0.05) and GP (14.8 +/- 0.8 mol.min(-1).kg(-1); P