Gene regulatory landscape in osteoblast differentiation
Gene regulatory landscape in osteoblast differentiation
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DOI：
10.1016/j.bone.2020.115458
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发表时间：
2020-08-01
期刊：
影响因子：
4.1
通讯作者：
Ohba, Shinsuke
中科院分区：
文献类型：
--
作者：
Hojo, Hironori;Ohba, Shinsuke
成骨细胞（一种骨形成细胞群）的发育与骨骼的发育相结合，骨骼创造了我们的身体框架并塑造了身体。在过去的二十年中，遗传学研究揭示了这一过程的分子框架，即转录调控因子和信号通路协调细胞命运的决定和成骨细胞的分化在空间和时间的方式。最近出现的全基因组研究提供了额外的层的理解成骨细胞分化过程中的基因调控景观，使我们能够获得新的洞察力的关键监管机构的行动模式，功能之间的相互作用的监管约束增强，表观遗传法规，和复杂的性质的监管投入。在这篇综述中，我们总结了目前的理解成骨细胞的转录调控，在基因调控景观。
The development of osteoblasts, a bone-forming cell population, occurs in conjunction with development of the skeleton, which creates our physical framework and shapes the body. In the past two decades, genetic studies have uncovered the molecular framework of this process-namely, transcriptional regulators and signaling pathways coordinate the cell fate determination and differentiation of osteoblasts in a spatial and temporal manner. Recently emerging genome-wide studies provide additional layers of understanding of the gene regulatory landscape during osteoblast differentiation, allowing us to gain novel insight into the modes of action of the key regulators, functional interaction among the regulator-bound enhancers, epigenetic regulations, and the complex nature of regulatory inputs. In this review, we summarize current understanding of the transcriptional regulation in osteoblasts, in terms of the gene regulatory landscape.