Modulatory effects of ZYM-201 sodium succinate on dietary-induced hyperlipidemic conditions
Modulatory effects of ZYM-201 sodium succinate on dietary-induced hyperlipidemic conditions
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DOI：
10.1691/ph.2011.1512
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发表时间：
2011-10-01
期刊：
影响因子：
1.6
通讯作者：
Cho, Jae Youl
中科院分区：
文献类型：
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作者：
Choi, Jongwon;Yu, Tao;Cho, Jae Youl
地榆（Sanguisorba officinalis）在韩国、中国和日本是一种众所周知的有价值的药用植物，传统上用于治疗炎症和代谢性疾病，如腹泻、慢性肠道感染、十二指肠溃疡和出血。本文研究了从地榆中分离得到的一种化学修饰的三萜苷（ZYM-201琥珀酸钠）对高脂血症大鼠的降血脂作用。经口给予ZYM-201琥珀酸钠（1 - 10 mg/kg）剂量依赖性地减弱了饮食诱导的体重和肝脏重量增加。在10 mg/kg时，该化合物还将甘油三酯（TG）和总胆固醇的血清水平升高逆转至正常水平。此外，防止了血清和肝脏中高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）值的失衡。最后，该化合物既能阻断脂质过氧化物和羟自由基的产生，又能提高肝脏超氧化物歧化酶（SOD）的活性。因此，我们的数据有力地表明，ZYM-201琥珀酸钠可以在调节高血压疾病中发挥作用，这可以用作治疗相关疾病如动脉粥样硬化和血管疾病的有价值的药物。
Sanguisorba officinalis, a well known and valuable medicinal plant in Korea, China and Japan has been used traditionally for the treatment of inflammatory and metabolic diseases such as diarrhea, chronic intestinal infections, duodenal ulcers, and bleeding. We studied the anti-hyperlipidemic effects of a chemically modified triterpenoid glycoside (ZYM-201 sodium succinate) isolated from Sanguisorba officinalis in rats in which hyperlipidemia had been induced by dietary administration of cholesterol and cholic acid. Oral administration of ZYM-201 sodium succinate (1 to 10 mg/kg) dose-dependently attenuated the diet-induced increases in body and liver weights. At 10 mg/kg, this compound also reversed the enhancement of serum levels of triglycerides (TG) and total cholesterol back to normal levels. In addition, imbalances in both serum and hepatic values of high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) were prevented. Finally, this compound both blocked the generation of lipid peroxide and hydroxyl radicals and enhanced the activity of superoxide dismutase (SOD) in liver. Therefore, our data strongly suggest that ZYM-201 sodium succinate could play a role in modulating hyperlipidemic conditions, which could be used as a valuable remedy for the treatment of relevant disorders such as atherosclerosis and vascular diseases.