Mesothelioma - Update on Diagnostic Strategies.
Mesothelioma - Update on Diagnostic Strategies.
复制标题
间皮瘤 - 诊断策略更新。
DOI：
10.1097/cpm.0b013e318272ce61
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发表时间：
2012
影响因子：
--
通讯作者：
Kamp,DavidW
中科院分区：
文献类型：
--
作者：
Rosario,CarmenM;Lin,Xiaoqi;Kamp,DavidW
恶性胸膜间皮瘤（MPM）是一种罕见的、高度侵袭性的恶性肿瘤，累及胸膜和腹膜浆膜。石棉和间皮瘤之间的关系是在 20 世纪 60 年代确立的；距 20 世纪 50 年代石棉工业生产开始已近一个世纪。鉴于 MPM 多变的临床表现和不良预后，及时、准确的诊断对临床医生将 MPM 与良性石棉胸腔积液和转移性癌区分开来提出了挑战。在这篇综述中，我们介绍了一名 MPM 患者，然后回顾了新出现的流行病学趋势和临床表现。我们的主要重点是回顾越来越多的证据，这些证据支持细胞病理学免疫染色和血清生物标志物在 MPM 的诊断和管理中的重要作用。
Malignant pleural mesothelioma (MPM) is a rare, highly aggressive malignancy involving the serosa of the pleura and peritoneum. The relationship between asbestos and mesothelioma was established in the 1960s; nearly a century after industrial production of asbestos began in the 1850s. Given the protean clinical manifestations and poor prognosis of MPM, a prompt, accurate diagnosis challenges clinicians in distinguishing MPM from benign asbestos pleural effusions and metastatic carcinomas. In this review, we present a patient with MPM and then review the emerging epidemiologic trends and clinical manifestations. Our primary focus is to review the accumulating evidence supporting an important role for cytopathologic immunostains and serum biomarkers in the diagnosis and management of MPM.