Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in atherogenesis
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in atherogenesis
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DOI：
10.1016/s1050-1738(01)00079-2
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发表时间：
2001-01-01
影响因子：
9.3
通讯作者：
Kita, T
中科院分区：
文献类型：
--
作者：
Kume, N;Kita, T
Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) is a type-II membrane protein belonging to the C-type lectin family molecules, which can act as a cell surface endocytosis receptor for atherogenic oxidized LDL (Ox-LDL). LOX-1 is synthesized as a 40 kDA precursor protein with N-linked high mannose-type carbohydrate, which is further glycosylated and processed into a 50kDA mature form. LOX-1 expression is not constitutive but can be induced by proinflammatory, oxidative, and mechanical stimuli. In addition to endothelial cells, macrophages and activated vascular smooth muscle cells express LOX-1. In vivo, endothelial cells covering early atherosclerotic lesions and macrophages and smooth muscle cells accumulated in the intima of advanced atherosclerotic plaques express LOX-1. LOX-1 is cleaved at membrane proximal extracellular domain by some protease activities and released from the cell surface. Measurement of soluble LOX-1 in vivo may provide novel diagnostic strategy for the evaluation and prediction of atherosclerosis nad vascular diseases. (C) 2001, Elsevier Science Inc.
