CRP and ASDAS are associated with future elevated arterial stiffness, a risk marker of cardiovascular disease, in patients with ankylosing spondylitis: results after 5-year follow-up
CRP and ASDAS are associated with future elevated arterial stiffness, a risk marker of cardiovascular disease, in patients with ankylosing spondylitis: results after 5-year follow-up
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DOI：
10.1136/annrheumdis-2014-206773
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发表时间：
2015-08-01
影响因子：
27.4
通讯作者：
Provan, Sella A.
中科院分区：
文献类型：
--
作者：
Berg, Inger Jorid;Semb, Anne Grete;Provan, Sella A.
目的探讨强直性脊柱炎(AS)患者5年随访中动脉僵硬度升高的相关因素。方法2003年记录C反应蛋白(CRP)、血沉(ESR)、Bath AS疾病活动指数(BASDAI)和AS疾病活动评分(ASDAS)，2008/2009年记录动脉僵硬指数(AIX)和脉搏波速度(PWV)。根据基线CRP、血沉和BASDAI将患者分为四个分位数和四个ASDAS组。趋势分析使用ANCOVA(AIX/PWV作为因变量)，使用单独的CRP、ESR、BASDAI和ASDAS模型(调整年龄和性别)。在多元线性回归模型中确定了未来AIX和PWV水平的独立预测因素。结果总共有85名患者参与。随访时CRP、ESR和ASDAS的基线值升高与AIX升高相关(p(趋势)分别为0.01、0.05和0.04)。PWV也有类似的非显著模式。在多因素分析中，基线CRP和ASDAS与未来AIX升高独立相关(p分别为0.03和0.02)。在多变量PWV模型中，CRP和ASDAS的结果无统计学意义。结论基线CRP和ASDAS与AS患者未来动脉僵硬指数的升高相关，支持疾病活动与AS患者未来心血管疾病的风险相关。
Objective To identify factors associated with elevated arterial stiffness in a 5-year follow-up of patients with ankylosing spondylitis (AS).Methods C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath AS disease activity index (BASDAI) and AS disease activity score (ASDAS) were recorded in 2003, and arterial stiffness (Augmentation Index (AIx) and pulse wave velocity (PWV)) in 2008/2009. Patients were grouped into quartiles according to baseline CRP, ESR and BASDAI and four ASDAS groups. Trend analyses were performed using ANCOVA (AIx/PWV as dependent variable) with separate models for CRP, ESR, BASDAI and ASDAS (age and gender adjusted). Independent predictors of future AIx and PWV levels were identified in multivariate linear regression models.Results In total, 85 patients participated. Increasing baseline values of CRP, ESR and ASDAS were associated with elevated AIx on follow-up (p(trend) 0.01, 0.05 and 0.04, respectively). Similar non-significant patterns were seen for PWV. In the multivariate analyses, baseline CRP and ASDAS were independently associated with future elevated AIx (p=0.03 and 0.02, respectively). In the multivariate PWV model, results for CRP and ASDAS were non-significant.Conclusions Baseline CRP and ASDAS were associated with future elevated arterial stiffness measured as AIx, supporting that disease activity is related to future risk of cardiovascular disease in patients with AS.