A self-delivery membrane system for enhanced anti-tumor therapy
A self-delivery membrane system for enhanced anti-tumor therapy
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用于增强抗肿瘤治疗的自递送膜系统
DOI：
10.1016/j.biomaterials.2018.01.037
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发表时间：
2018-04-01
期刊：
影响因子：
14
通讯作者：
Zhang, Xian-Zheng
中科院分区：
文献类型：
--
作者：
Qiu, Wen-Xiu;Zhang, Ming-Kang;Zhang, Xian-Zheng
如今，细胞膜靶向治疗因能避开细胞屏障而具有高效的抗肿瘤作用，受到了广泛关注。在这项研究中，将治疗剂偶联的嵌合肽（Cp）锚定在破裂的癌细胞膜（CCCM）中，构建了一种自递送膜系统（MCp），它能够实现精确的细胞膜靶向治疗。研究发现，与Cp相比，MCp能够以更长的滞留时间靶向癌细胞膜，这对体内应用至关重要。其卓越的细胞膜靶向能力归因于CCCM表面的特定蛋白质（粘着斑蛋白、粘着斑激酶、RHO家族蛋白和整合素）。重要的是，M - Cp能够促进肿瘤特异性免疫反应，当与M - Cp中的治疗剂联合使用时，进一步增强了抗肿瘤效果。此外，这种自递送膜系统可通过改变治疗剂以及CCCM作为细胞膜靶向治疗的模板，这一策略将为各种细胞膜靶向治疗开辟新的途径。（C）2018爱思唯尔有限公司。保留所有权利。
Nowadays, cell membrane targeting therapy has drawn much attention for its high anti-tumor effect by avoiding the cellular barriers. In this study, therapeutic agent conjugated chimeric peptide (Cp) was anchored in cracked cancer cell membranes (CCCM) to construct a self-delivery membrane system (MCp), which could relize precise cell membrane targeting therapy. It was found that compared with Cp, MCp could target to the cancer cell membrane with longer retention time, which is very crucial for in vivo applications. And the superior cell membrane targeting ability was attributed to the specific proteins (focal adhesion proteins, focal adhesion kinase, RHO family proteins, and integrin) on the CCCM surface. Importantly, the M-Cp could promote tumor-specific immune response, which further enhanced antitumor effect when combined with therapeutic agents in M-Cp. What's more, this self-delivery membrane system could be used as a template for cell membrane targeting therapy by changing the therapeutic agents as well as the CCCM, and this strategy would open a new window for various cell membrane targeting therapy. (C) 2018 Elsevier Ltd. All rights reserved.