Multicolor-FISH applied to resolve complex chromosomal changes in a case of T-ALL (FAB L2)
Multicolor-FISH applied to resolve complex chromosomal changes in a case of T-ALL (FAB L2)
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应用多色 FISH 解决 T-ALL 病例中复杂的染色体变化 (FAB L2)
DOI：
10.1159/000094212
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发表时间：
2006
影响因子：
1.7
通讯作者：
R. Aroutiounian
中科院分区：
文献类型：
--
作者：
H. Mkrtchyan;M. Glaser;M. Gross;U. Wedding;K. Höffken;T. Liehr;C. Karst;R. Aroutiounian
我们报告一例临床诊断为急性淋巴细胞白血病(ALL)的患者，其部分未记录的复杂易位事件尤其涉及5号、9号和18号染色体。在GTG-带水平，分析的细胞中有20%的核型异常。用光谱核型分析(SKY)和多色显带分析(MCB)对该复杂核型进行了更详细的研究。因此，可以非常准确地描述核型，总而言之，检测到三个不同的克隆，反映了该患者核型进化的高速率。
We report on a patient with a clinically diagnosed acute lymphoblastic leukemia (ALL) with partial unrecorded complex translocation events especially involving chromosomes 5, 9 and 18. At the GTG-band level the karyotype was abnormal in 20% of the analyzed cells. The complex karyotype was studied in more detail by spectral karyotyping (SKY) and multicolor banding (MCB) to characterize it in more detail. Thus, the karyotype could be described very accurately and in summary three different clones were detected, reflecting a high rate of karyotypic evolution in this patient.