Type-specific concordance in young diabetic monozygotic twins.
Type-specific concordance in young diabetic monozygotic twins.
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年轻糖尿病同卵双胞胎的类型特异性一致性。
DOI：
10.1007/978-1-4684-5616-5_32
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发表时间：
1988
影响因子：
--
通讯作者：
Mack,TM
中科院分区：
文献类型：
--
作者：
Kumar,D;Gemayel,NS;Gill,SK;Bray,GA;Roy-Burman,P;Deapen,D;Mack,TM
1972年，Tattersall和Pyke（1）指出，单卵双胞胎糖尿病的一致性水平取决于指数双胞胎糖尿病发病的年龄。如果糖尿病在40岁之前发生，随后的一致性估计为53%;当双胞胎指数在诊断时超过40岁时，它增加到92%。随后已经认识到，将糖尿病患者分类为I型糖尿病是不可能的。（胰岛素依赖型）和2（非胰岛素依赖性）仅基于年龄是不够的（2），明尼苏达州奥姆斯特德县的流行病学观察显示，尽管所有在生命的前十年中发病的糖尿病病例都是胰岛素依赖性的，在第二个和第三个十年中患糖尿病的人分别占37%和50%，他们实际上是非胰岛素依赖型病例（3）。在东芬兰的一项人群研究中，Laakso和Pyorala（4）也发现了年轻患者糖尿病类型的异质性。大约7%和20%的糖尿病患者在第三和第四个十年发病，是非胰岛素依赖型。可以想象，Tattersall和Pyke（1）所描述的40岁以前发病的单卵双胞胎也是一个混合组。
In 1972, Tattersall and Pyke (1) indicated that the level of concordance for diabetes among monozygotic twins depended upon the age of onset of diabetes in the index twin. If diabetes developed before 40 years of age, the subsequent concordance was estimated at 53%; it increased to 92% when the index twin was older than 40 years at diagnosis. It has been realized subsequently that classification of diabetic patients into Type I (insulin dependent) and 2 (non-insulin dependent) on the basis of age alone is in-sufficient (2), Epidemiologic observations in Olmsted County, Minnesota have revealed that while all cases with the onset of diabetes in the first decade of life were insulin dependent, those who became diabetic in the second and third decade included 37% and 50% respectively, who actually were non-insulin dependent cases (3). In a population study from East Finland, Laakso and Pyorala (4) also found heterogeneity of the type of diabetes among young patients. Approximately 7% and 20% of those cases with the onset of diabetes in the third and fourth decade were non-insulin dependent. It is conceivable that the monozygotic twins with onset of diabetes before 40 years of age described by Tattersall and Pyke (1) were also a mixed group.