BODY-WEIGHT AND MORTALITY AMONG WOMEN
BODY-WEIGHT AND MORTALITY AMONG WOMEN
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DOI：
10.1056/nejm199509143331101
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发表时间：
1995-09-14
影响因子：
158.5
通讯作者：
SPEIZER, FE
中科院分区：
文献类型：
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作者：
MANSON, JE;WILLETT, WC;SPEIZER, FE
背景尽管进行了大量的研究，但体重与总体死亡率之间的关系仍存在争议。我们研究了体重指数（定义为体重（公斤）除以身高（米）的平方）与总体死亡率和特定原因导致的死亡率之间的关系，研究对象为参加前瞻性护士健康研究的115，195名美国女性。这些妇女年龄在30至55岁之间，在1976年没有已知的心血管疾病和癌症。在16年的随访中，我们记录了4726例死亡，其中881例死于心血管疾病，2586例死于癌症，1259例死于其他原因。在仅调整年龄的分析中，我们观察到体重指数和总死亡率之间的J形关系。当对从不吸烟的妇女进行单独检查时，在较瘦的妇女中没有观察到风险增加，体重和死亡率之间出现了更直接的关系（P趋势
Background. The relation between body weight and overall mortality remains controversial despite considerable investigation.Methods. We examined the association between body-mass index (defined as the weight in kilograms divided by the square of the height in meters) and both overall mortality and mortality from specific causes in a cohort of 115,195 U.S. women enrolled in the prospective Nurses' Health Study. These women were 30 to 55 years of age and free of known cardiovascular disease and cancer in 1976. During 16 years of follow-up, we documented 4726 deaths, of which 881 were from cardiovascular disease, 2586 from cancer, and 1259 from other causes.Results. In analyses adjusted only for age, we observed a J-shaped relation between body-mass index and overall mortality. When women who had never smoked were examined separately, no increase in risk was observed among the leaner women, and a more direct relation between weight and mortality emerged (P for trend