CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients - From The Danish "MALOVA" Ovarian Cancer Study
CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients - From The Danish "MALOVA" Ovarian Cancer Study
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DOI：
10.1016/j.ygyno.2006.09.028
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发表时间：
2007-03-01
影响因子：
4.7
通讯作者：
Hogdall, Claus K.
中科院分区：
文献类型：
--
作者：
Hogdall, Estrid V. S.;Christensen, Lise;Hogdall, Claus K.
目标.探讨卵巢交界性和浸润性上皮性肿瘤组织中CA 125的表达水平。其次，探讨卵巢癌组织中CA 125表达水平与卵巢癌临床病理参数及血清CA 125水平的相关性，并探讨卵巢癌组织中CA 125表达水平对卵巢癌患者预后的价值。我们设计了组织阵列（TA），并分析了778名丹麦卵巢肿瘤妇女组织中的CA 125表达。同时对382例OC患者术前采集相应的血液标本。对于交界性卵巢肿瘤和OC患者，与粘液性、子宫内膜样和其他亚型中的阳性肿瘤百分比相比，在浆液性亚型中发现了显著更多的CA 125表达阳性肿瘤（无表达vs.表达）（p < 0.00001，p < 0.00001）。类似地，在升高的血清CA 125水平和升高的CA 125组织表达水平之间发现显著正相关（N=382个I-IN OC，斯皮尔曼p=0.31，p < 0.0001）（N=206个III OC，斯皮尔曼p=0.30，p < 0.0001）。我们发现无CA 125组织表达的III/V期OC患者的生存期显著短于有CA 125组织表达的III/IV期OC患者（p=0.0003）。我们的研究发现，组织CA 125表达缺乏晚期原发性OC肿瘤的丹麦妇女生存率低，可能是有价值的选择患者作为合格的候选人为个体化治疗。(c)2006年爱思唯尔公司All rights reserved.
Objectives. To determine the CA125 tissue expression levels in borderline and invasive epithelial ovarian tumor tissues. Secondly, to evaluate whether CA125 tissue expression levels correlate with clinico-pathological parameters and serum CA125 levels and finally to investigate the prognostic value of tissue CA125 expression levels in ovarian cancer (OC) patients.Methods. We designed tissue arrays (TA) and analyzed the CA125 expression in tissues from 778 Danish women with an ovarian tumor. Furthermore, corresponding preoperative blood samples obtained before surgery were collected from 382 women with OC.Results. Significantly more CA125 expression positive tumors (no expression vs. expression) were found in the serous subtype compared to the percentage of positive tumors in mucinous, endometroid and other subtypes for patients both with borderline ovarian tumors and with OC (p < 0.00001, p < 0.00001). Similarly, a positive significant correlation was found between elevated serum CA125 levels and elevated levels of CA125 tissue expression (N=382 stage I-IN OC, Spearman p=0.31, p < 0.0001) (N=206 stage III OC, Spearman p=0.30, p < 0.0001). We found a significantly shorter survival for stage III/V OC patients with no CA125 tissue expression compared to stage III/IV OC patients with positive CA125 tissue expression (p=0.0003).Conclusion. Our finding that tissue CA125 expression was lacking in late stage primary OC tumor of Danish women with poor survival may be of value in selecting patients as eligible candidates for individually based treatments. (c) 2006 Elsevier Inc. All rights reserved.