Grid cell firing patterns signal environmental novelty by expansion
Grid cell firing patterns signal environmental novelty by expansion
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DOI：
10.1073/pnas.1209918109
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发表时间：
2012-10-23
影响因子：
11.1
通讯作者：
Burgess, Neil
中科院分区：
文献类型：
--
作者：
Barry, Caswell;Ginzberg, Lin Lin;Burgess, Neil
海马结构在表征动物的位置和检测环境新奇性以创建或更新这些表征方面起着关键作用。然而，后一种功能背后的机制尚不清楚。在这里，我们表明，环境的新奇导致网格细胞的空间放电模式，扩大规模和减少的规律性，恢复到熟悉的规模，因为环境变得熟悉。同时记录的位置细胞放电领域重新映射，并表现出较小的，暂时的扩张。网格扩展提供了一个潜在的机制，新奇的信号，并可能提高新的海马表征的形成，而随后的规模缓慢减少提供了一个潜在的熟悉信号。
The hippocampal formation plays key roles in representing an animal's location and in detecting environmental novelty to create or update those representations. However, the mechanisms behind this latter function are unclear. Here, we show that environmental novelty causes the spatial firing patterns of grid cells to expand in scale and reduce in regularity, reverting to their familiar scale as the environment becomes familiar. Simultaneously recorded place cell firing fields remapped and showed a smaller, temporary expansion. Grid expansion provides a potential mechanism for novelty signaling and may enhance the formation of new hippocampal representations, whereas the subsequent slow reduction in scale provides a potential familiarity signal.