Effect of Serum Triglycerides on Clinical Outcomes in Acute Pancreatitis: Findings From a Regional Integrated Health Care System.
Effect of Serum Triglycerides on Clinical Outcomes in Acute Pancreatitis: Findings From a Regional Integrated Health Care System.
复制标题
DOI：
10.1097/mpa.0000000000000860
复制
发表时间：
2017-08
期刊：
影响因子：
2.9
通讯作者：
Wu BU
中科院分区：
文献类型：
--
作者：
Sue LY;Batech M;Yadav D;Pandol SJ;Blumentals WA;von Krusenstiern LS;Chen W;Wu BU
本研究的目的是评估血清甘油三酯对急性胰腺炎患者发生多器官或持续性器官衰竭的影响。在2006年至2013年因急性胰腺炎住院的患者中进行了一项回顾性队列研究。比较入院前和入院72小时内测量的甘油三酯水平。此外，还评估了甘油三酯水平对急性胰腺炎住院期间发生多器官衰竭或持续性器官衰竭的影响。在2519例患者中，267例（10.6%）患者发生器官衰竭，其中75例患者发生多系统器官衰竭，82例患者发生持续性器官衰竭。发生器官衰竭的患者的甘油三酯水平最初远高于未发生器官衰竭的患者，但在入院后72小时，接近未发生器官衰竭的患者水平。大约8%的患者的甘油三酯水平大于500 mg/dL，其中大多数在入院前具有类似的高水平。在急性胰腺炎住院患者中，甘油三酯水平升高与多器官衰竭或持续性器官衰竭的发生相关。入院时甘油三酯水平高的患者在入院前可能有高甘油三酯水平。
The aim of this study was to evaluate the effect of serum triglycerides on the development of multiple or persistent organ failure in patients with acute pancreatitis. A retrospective cohort study was conducted among patients hospitalized for acute pancreatitis between 2006 and 2013. Triglyceride levels measured before and within 72 hours of admission were compared. In addition, the effect of triglyceride levels on the development of multiple or persistent organ failure during hospitalization for acute pancreatitis was assessed. Among 2519 patients, 267 patients (10.6%) developed organ failure, of which 75 patients developed multiple system organ failure and 82 patients developed persistent organ failure. Triglyceride levels in patients who developed organ failure were initially much higher than in patients who did not develop organ failure, but by 72 hours into admission, approached levels of patients who did not develop organ failure. Approximately 8% of patients had triglyceride levels greater than 500 mg/dL, the majority of which had similarly high levels before admission. Increased triglyceride levels were associated with the development of multiple or persistent organ failure among patients hospitalized with acute pancreatitis. Patients with high triglyceride levels at the time of admission were likely to have high triglyceride levels before admission.