Myeloid-derived suppressor cells in autoimmune diseases
Myeloid-derived suppressor cells in autoimmune diseases
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DOI：
10.2492/inflammregen.34.124
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发表时间：
2014
影响因子：
8.1
通讯作者：
W. Fujii;E. Ashihara;Y. Kawahito
中科院分区：
文献类型：
--
作者：
W. Fujii;E. Ashihara;Y. Kawahito
髓源性抑制细胞（MDSC）是髓源性的并且能够抑制T细胞免疫应答。尽管MDSC通过抑制T细胞免疫应答和诱导免疫耐受在肿瘤进展中发挥重要作用，但MDSC在自身免疫性疾病如类风湿性关节炎中的作用仍存在争议。很难解释为什么尽管MDSC的募集和积累会发生自身免疫性疾病，这应该会抑制免疫反应。在这里，我们回顾了目前的知识MDSC在自身免疫性疾病的动物模型和人类自身免疫性疾病中所发挥的作用。我们认为，至少在某些情况下，MDSC可以预防自身免疫性疾病的进一步发展，并提出了基于内源性MDSC的自身免疫性疾病的新治疗策略。
Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T cell immune responses. Although MDSCs play important roles in tumor progression by suppressing T cell immune responses and inducing immune tolerance, the roles of MDSCs in autoimmune diseases such as rheumatoid arthritis remain controversial. It is difficult to explain why autoimmune diseases occur despite the recruitment and accumulation of MDSCs, which should suppress the immune response. Here, we review the current knowledge regarding the roles played by MDSCs in animal models of autoimmune disease and in human autoimmune disease. We propose that, at least in some cases, MDSCs prevent further progression of autoimmune disorders and suggest novel therapeutic strategies for autoimmune diseases based on the use of endogenous MDSCs.