Association of Serum Cotinine Levels and Hypertension in Never Smokers
Association of Serum Cotinine Levels and Hypertension in Never Smokers
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DOI：
10.1161/hypertensionaha.112.198218
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发表时间：
2013-02-01
期刊：
影响因子：
8.3
通讯作者：
Shankar, Anoop
中科院分区：
文献类型：
--
作者：
Alshaarawy, Omayma;Xiao, Jie;Shankar, Anoop
高血压是一个主要的公共卫生问题。因此，确定新的高血压风险因素，包括广泛流行的环境暴露，是很重要的。积极吸烟是众所周知的高血压和心血管疾病的危险因素。然而，没有研究调查二手烟暴露（通过血清可替宁客观测量）与从不吸烟者的高血压之间的关系。我们对2005-2008年国家健康和营养调查中的2889名从不吸烟者进行了检查。我们感兴趣的暴露是从不吸烟者中的二手烟暴露，通过血清可替宁水平估计，我们的主要结局是高血压（n=1004）。我们发现在从不吸烟者中，较高的血清可替宁水平与高血压呈正相关。与血清可替宁水平= 0.218 ng/mL的患者相比，为1.44（1.01-2.04）。此外，较高的血清可替宁与收缩压的平均变化呈正相关（比值比[95%置信区间]，3.24 [0.86-5.63]; P=0.0061）。然而，与舒张压无相关性。总之，在从不吸烟者中，通过血清可替宁水平客观测量的较高二手烟暴露与收缩压和高血压相关，与年龄、性别、种族、教育、饮酒、体重指数、糖化血红蛋白、总胆固醇和其他混杂因素无关。（高血压。2013;61：304-308）。
Hypertension is a major public health problem. Identifying novel risk factors for hypertension, including widely prevalent environmental exposures, is therefore important. Active smoking is a well-known risk factor for hypertension and cardiovascular diseases. However, there are no studies investigating the relationship between secondhand smoke exposure, measured objectively by serum cotinine, and high blood pressure among never smokers. We examined 2889 never smokers from the National Health and Nutrition Examination Survey 2005-2008. Our exposure of interest was secondhand smoke exposure among never smokers, estimated by serum cotinine level, and our main outcome was hypertension (n=1004). We found that in never smokers, higher serum cotinine levels were positively associated with hypertension. In comparison with those with serum cotinine levels = 0.218 ng/mL was 1.44 (1.01-2.04). In addition, higher serum cotinine was positively associated with mean change in systolic blood pressure (odds ratio [95% confidence interval], 3.24 [0.86-5.63]; P=0.0061). However, no association was present with diastolic blood pressure. In conclusion, in never smokers, higher secondhand smoke exposure measured objectively by serum cotinine levels was found to be associated with systolic blood pressure and hypertension independent of age, sex, ethnicity, education, alcohol drinking, body mass index, glycohemoglobin, total cholesterol, and other confounders. (Hypertension. 2013;61:304-308.)