C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction
C(-260)→T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction
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DOI：
10.1161/01.cir.99.25.3218
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发表时间：
1999-06-29
期刊：
影响因子：
37.8
通讯作者：
Poledne, R
中科院分区：
文献类型：
--
作者：
Hubacek, JA;Pit'ha, J;Poledne, R
背景-单核细胞的CD14受体是革兰氏阴性菌包膜内毒素（脂多糖）激活单核细胞/巨噬细胞的重要介质。我们鉴定了 CD14 受体中的多态性，并检查了该遗传标记是否影响单核细胞上 CD14 受体的表达并影响心肌梗死的易感性。方法和结果 - 我们鉴定了 C(-260)-->T 核苷酸变化，在 CD14 基因的启动子中产生了血红素多态性。在 178 名男性患者中测定了多态性
Background-The CD14 receptor of monocytes is an important mediator for the activation of monocytes/macrophages by endotoxins from the envelope of Gram-negative bacteria (lipopolysaccharides). We identified a polymorphism in the CD14 receptor and examined whether this genetic marker influenced the expression of the CD14 receptor on monocytes and affected the predisposition to myocardial infarction.Methods and Results-We identified a C(-260)-->T nucleotide change, creating a Haem polymorphism in the promoter of the CD14 gene. The polymorphism was determined in 178 male patients