Immunologic abnormalities in patients with hemophilia A.
Immunologic abnormalities in patients with hemophilia A.
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A 型血友病患者的免疫学异常。
DOI：
10.1016/s0022-3476(83)80459-4
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Ammann,AJ
中科院分区：
文献类型：
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作者：
Weintrub,PS;Koerper,MA;AddiegoJr,JE;Drew,WL;Lennette,ET;Miner,R;Cowan,MJ;Ammann,AJ
为了解健康人血友病A的免疫状态，我们对21例患者进行了T细胞免疫功能的研究，其中10例仅给予冷沉淀物，11例给予浓缩因子。因子VIII组患者辅助性/抑制性T细胞比率显著降低。与对照组相比，两组患者的单个核细胞对植物血凝素和正常混合淋巴细胞培养的反应均减弱。T细胞数量或功能的异常与巨细胞病毒、爱泼斯坦-巴尔病毒或乙肝抗体的存在无关，照顾血友病A患者的医生应该意识到，没有症状的人可能有免疫缺陷的早期证据。
To assess the immunologic status of healthy persons with hemophilia A, we performed studies of T cell immunity in 21 patients, 10 given only cryoprecipitate and 11 given factor VIII concentrate. Patients in the factor VIII group had significantly decreased helper/suppressor T cell ratios. Both groups had diminished mononuclear cell response to phytohemagglutinin and normal mixed lymphocyte culture, compared with controls. Abnormalities in T cell number or function did not correlate with the presence of antibody to cytomegalovirus, Epstein-Barr virus, or hepatitis B. Physicians caring for patients with hemophilia A should realize that asymptomatic individuals may have early evidence of immunodeficiency.