Fast 3D ultrashort echo-time spiral projection imaging using golden-angle: A flexible protocol for in vivo mouse imaging at high magnetic field
Fast 3D ultrashort echo-time spiral projection imaging using golden-angle: A flexible protocol for in vivo mouse imaging at high magnetic field
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DOI：
10.1002/mrm.26263
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发表时间：
2017-05-01
影响因子：
3.3
通讯作者：
Miraux, Sylvain
中科院分区：
文献类型：
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作者：
Castets, Charles R.;Lefrancois, William;Miraux, Sylvain
目的开发一种基于螺旋投影成像（SPI）和交错黄金角方法的快速三维（3D）k空间编码方法，并在小动物模型上验证这种新颖的序列。方法开发了一个盘状轨迹，其中每个盘都包含螺旋。 3D 编码是通过以黄金角度倾斜磁盘来执行的。首先计算不同 T2* 值下的清晰度。然后，使用可变欠采样率在体模上测量锐度。最后，通过小鼠全脑飞行时间血管造影和超小超顺磁氧化铁（USPIO）增强自由呼吸肝血管造影验证了该采样方法。结果体外结果证明了该方法对于短T2*和高欠采样率的鲁棒性。体内实验表明能够正确检测大脑中的小血管，采集时间短于 1 分钟。自由呼吸小鼠肝脏血管造影显示该协议对运动和流动伪影不敏感，并且能够实现呼吸过程中肝脏运动的可视化。结论这里实施的方法允许以高欠采样率进行快速 3D k 空间采样。将中心向外螺旋的优点与黄金角度方法的灵活性相结合可能会对实时成像产生重大影响。 Magn Reson Med 77:1831-1840, 2017。(c) 2016 年国际医学磁共振学会
PurposeTo develop a fast three-dimensional (3D) k-space encoding method based on spiral projection imaging (SPI) with an interleaved golden-angle approach and to validate this novel sequence on small animal models.MethodsA disk-like trajectory, in which each disk contained spirals, was developed. The 3D encoding was performed by tilting the disks with a golden angle. The sharpness was first calculated at different T2* values. Then, the sharpness was measured on phantom using variable undersampling ratios. Finally, the sampling method was validated by whole brain time-of-flight angiography and ultrasmall superparamagnetic iron oxide (USPIO) enhanced free-breathing liver angiography on mouse.ResultsThe in vitro results demonstrated the robustness of the method for short T2* and high undersampling ratios. In vivo experiments showed the ability to properly detect small vessels in the brain with an acquisition time shorter than 1min. Free-breathing mice liver angiography showed the insensitivity of this protocol toward motions and flow artifacts, and enabled the visualization of liver motion during breathing.ConclusionsThe method implemented here allowed fast 3D k-space sampling with a high undersampling ratio. Combining the advantages of center-out spirals with the flexibility of the golden angle approach could have major implications for real-time imaging. Magn Reson Med 77:1831-1840, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine