Novel composite MRI scale correlates highly with disability in multiple sclerosis patients
Novel composite MRI scale correlates highly with disability in multiple sclerosis patients
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DOI：
10.1016/j.msard.2015.08.009
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发表时间：
2015-11-01
影响因子：
4
通讯作者：
Bielekova, Bibiana
中科院分区：
文献类型：
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作者：
Kosa, Peter;Komori, Mika;Bielekova, Bibiana
了解基因型-表型关系或生物标志物的开发/验证需要通过关键表型性状的通用定量（如中枢神经系统（CNS）组织破坏）整合的大型多中心队列。我们假设，数学建模指导的生物学意义的组合，半定量MRI元素的特点是高信噪比将提供这种可靠的，通用的工具来测量中枢神经系统组织破坏。我们回顾性地对419名未经治疗的有或无神经系统疾病的受试者进行MRI扫描的15个元素进行了分级，同时对他们前瞻性获得的临床评分不知情。然后，我们使用305名受试者进行残疾指导的数学建模，以选择和联合收割机MRI元素，有非冗余的贡献，临床残疾，导致组合MRI量表（COMRIS）。我们在剩下的114名独立受试者上验证了我们的模型。COMRIS每次扫描平均需要5 - 10分钟来计算，并分别证明了扩展残疾状态量表（EDSS）、Scripps神经功能评定量表（SNRS）和符号数字模态测试（SDMT）神经功能残疾测量的高度显著（p <0.0001）和验证一致的斯皮尔曼相关系数（0.75、0.76和0.65）。由于COMRIS不受MRI扫描仪或协议的影响很大，即使存在一些运动伪影也可以计算，因此它不需要删失患者，并且它提供了不同队列的可比结果。因此，它代表了一种广泛可用的临床和研究工具，可以促进多中心研究和跨患者队列和研究项目的比较分析。由爱思唯尔公司出版
Understanding genotype-phenotype relationships or development/validation of biomarkers requires large multicenter cohorts integrated by universal quantification of crucial phenotypical traits, such as central nervous system (CNS) tissue destruction. We hypothesized that mathematical modeling-guided combination of biologically meaningful, semi-quantitative MRI elements characterized by high signal-to-noise ratio will provide such reliable, universal tool for measuring CNS tissue destruction. We retrospectively graded 15 elements in MRI scans performed in 419 untreated subjects with or without neurological diseases, while being blinded to their prospectively acquired clinical scores. We then used 305 subjects for disability-guided mathematical modeling to select and combine MRI elements that had non-redundant contributions to clinical disability, resulting in Combinatorial MRI Scale (COMRIS). We validated our model on the remaining 114 independent subjects. COMRIS requires 5-10 min per scan on average to compute and demonstrates highly significant (p < 0.0001) and validation-consistent Spearman correlation coefficients (0.75, 0.76, and 0.65) for the expanded disability status scale (EDSS), Scripps neurological rating scale (SNRS), and symbol digit modality test (SDMT) measures of neurological disability, respectively. Because COMRIS is not greatly influenced by MRI scanners or protocols and can be computed even in the presence of some motion artifacts, it does not require censoring out patients and it provides comparable results across different cohorts. As such, it represents a broadly available clinical and research tool that can facilitate multicenter research studies and comparative analyses across patient cohorts and research projects. Published by Elsevier B.V.