Neural and behavioral consequences of prenatal exposure to diazepam.
Neural and behavioral consequences of prenatal exposure to diazepam.
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产前接触地西泮的神经和行为后果。
DOI：
10.1159/000406884
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Miller,RK
中科院分区：
文献类型：
--
作者：
Kellogg,CK;Chisholm,J;Simmons,RD;Ison,JR;Miller,RK
近年来，越来越多的报告描述了产前暴露于许多精神治疗药物的长期影响[9，11，13，17，21]。这些报告提出了关于在怀孕期间适当使用这些药物的严重问题。然而，解释实验结果和临床应用所获得的信息需要考虑几个问题。在确定任何药物的产前毒性时，必须建立治疗、并发疾病和种属效应和药代动力学比较的作用。地西泮和其他镇静药是目前使用最广泛的处方药。许多临床报告表明，产前暴露于这些药物可能会导致新生儿出现各种调节功能障碍[8，20，22，23]。然而，母亲的压力已被证明会诱导后代的持久功能障碍[1，10，12，27]，并选择ataractic药物有效地用于控制各种形式的压力。虽然减轻压力的好处可能超过药物对后代的不良影响，但必须对药物的影响进行彻底的分析。
Reports describing long-lasting effects of prenatal exposure to many psychotherapeutic drugs have appeared in increasing numbers in recent years [9, 11, 13, 17, 21]. Such reports raise serious questions regarding the appropriate use of these drugs during pregnancy. However, interpretation of the experimental findings and the clinical application of information obtained necessitates consideration of several questions. The role of therapy, intercurrent disease and species comparisons for effects and pharmacokinetics must be established in determining the prenatal toxicity of any drug.The current studies on the effects of prenatal exposure of rats to dia-zepam (DZ) were designed with these guidelines in mind. Diazepam and other ataractic drugs are among the most widely prescribed compounds in use today. Numerous clinical reports have indicated that prenatal exposure to these drugs may yield a variety of regulatory dysfunctions in the neonate [8, 20, 22, 23]. However, maternal stress has been demonstrated to induce lasting dysfunction in the offspring [1, 10, 12, 27], and selected ataractic drugs are used effectively in the control of various forms of stress. While the benefits of stress reduction could outweigh drug-related adverse consequences to the offspring, a thorough analysis of effects of the drug must be made.